Casp6 Gene Summary [Mouse]
This gene encodes a member of the cysteine proteases that plays important roles in regulating apoptosis and neurodegeneration. The encoded protein is involved in the transmission of pain and axonal degeneration. Genetic deletion of this gene in mice results in the delay of axon pruning and protects from axon degeneration. [provided by RefSeq, Apr 2015]
Details
| Type | Protein Coding |
| Official Symbol | Casp6 |
| Official Name | caspase 6 [Source:MGI Symbol;Acc:MGI:1312921] |
| Ensembl ID | ENSMUSG00000027997 |
| Bio databases IDs | |
| Aliases | caspase 6 |
| Synonyms | caspase-6, CSP-6, LOC103689977, MCH2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Casp6 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- CASc
- endopeptidase
- cysteine-type peptidase
- cysteine endopeptidase
- peptidase
- protein binding
- identical protein binding
Pathways
Biological processes and signaling networks where the Casp6 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- Apoptosis Signaling
- Cytotoxic T Lymphocyte-mediated Apoptosis of Target Cells
- Death Receptor Signaling
- DNA damage-induced 14-3-3σ Signaling
- Endocannabinoid Cancer Inhibition Pathway
- Endothelin-1 Signaling
- HER-2 Signaling in Breast Cancer
- Huntington's Disease Signaling
- Molecular Mechanisms of Cancer
- Osteoarthritis Pathway
- p53 Signaling
- Role of Oct4 in Mammalian Embryonic Stem Cell Pluripotency
- Sphingosine-1-phosphate Signaling
- TNFR1 Signaling
- Tumoricidal Function of Hepatic Natural Killer Cells
- TWEAK Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- reperfusion injury
- microphthalmia
- Alzheimer disease
- systemic lupus erythematosus
- Huntington disease
- primary sclerosing cholangitis
- neuropathy
- aortic valve calcification
- Rett syndrome
- anophthalmia
role in cell
- cell death
- transmembrane potential
- activation in
- apoptosis
- expression in
- molecular cleavage in
- survival
- fragmentation
- degeneration
- killing
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- cytosol
- nucleoplasm
- perikaryon
- axons
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Casp6 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of programmed cell death
- execution phase of apoptosis
- positive regulation of necroptosis
- positive regulation of neuron apoptotic process
- hepatocyte apoptotic process
- epithelial cell differentiation
- activation of innate immune response
- signal transduction by p53 class mediator resulting in induction of apoptosis
- apoptotic process
- positive regulation of apoptotic process
- proteolysis
- pyroptosis
- protein autoprocessing
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- cysteine-type endopeptidase activity involved in execution phase of apoptosis
- cysteine-type endopeptidase activity
- cysteine-type peptidase activity
- cysteine-type endopeptidase activity involved in apoptotic process