Igf2bp3 Gene Summary [Mouse]
Predicted to enable N6-methyladenosine-containing RNA reader activity; mRNA 3'-UTR binding activity; and mRNA 5'-UTR binding activity. Predicted to be involved in CRD-mediated mRNA stabilization and nervous system development. Predicted to be located in P-body and cytoplasmic stress granule. Predicted to be active in cytosol and nucleus. Is expressed in several structures, including central nervous system; early conceptus; gonad; liver; and sensory organ. Orthologous to human IGF2BP3 (insulin like growth factor 2 mRNA binding protein 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Igf2bp3 |
| Official Name | insulin-like growth factor 2 mRNA binding protein 3 [Source:MGI Symbol;Acc:MGI:1890359] |
| Ensembl ID | ENSMUSG00000029814 |
| Bio databases IDs | |
| Aliases | insulin-like growth factor 2 mRNA binding protein 3 |
| Synonyms | 2610101N11Rik, Ab2-255, CT98, IMP-3, insulin-like growth factor 2 mRNA binding protein 3, KOC, KOC1, Koc13, mimp3, Neilsen, RGD1306512, VICKZ3 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Igf2bp3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA recognition motif (RRM) superfamily
- mRNA 3' UTR binding
- mRNA 5' UTR binding
- KH domain
- K homology (KH) RNA-binding domain, type I
- arCOG04150 universal archaeal KH domain protein
- RNA recognition motif
- protein binding activity, bridging
- K homology RNA-binding domain
- protein binding
- translation regulator
- RNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- epithelial neoplasia
- nasopharyngeal cancer
- squamous cell lung cancer
- lung squamous cell carcinoma
- endometrial adenocarcinoma
- biliary tract cancer
- non-small cell lung cancer
- cervical cancer
- colon adenocarcinoma
role in cell
- cell death
- expression in
- phosphorylation in
- binding in
- apoptosis
- cell viability
- growth
- proliferation
- invasion
- migration
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytoplasmic mRNA processing body
- Nucleus
- cytosol
- spliceosomes
- stress granule
- paraspeckle-like structures
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Igf2bp3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- nervous system development
- anatomical structure morphogenesis
- regulation of cytokine production
- CRD-mediated mRNA stabilization
- negative regulation of translation
- mRNA transport
- translation
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasmic stress granule
- cytoplasm
- cytoplasmic mRNA processing body
- cytosol
Molecular Function
What the gene product does at the molecular level
- translation regulator activity
- RNA binding
- protein binding
- mRNA 5'-UTR binding
- mRNA 3'-UTR binding