Dmgdh Gene Summary [Mouse]
This gene encodes an enzyme involved in the catabolism of choline, catalyzing the oxidative demethylation of dimethylglycine to form sarcosine. The enzyme is found as a monomer in the mitochondrial matrix, and uses flavin adenine dinucleotide and folate as cofactors. [provided by RefSeq, Jul 2013]
Details
| Type | Protein Coding |
| Official Symbol | Dmgdh |
| Official Name | dimethylglycine dehydrogenase precursor [Source:MGI Symbol;Acc:MGI:1921379] |
| Ensembl ID | ENSMUSG00000042102 |
| Bio databases IDs | |
| Aliases | dimethylglycine dehydrogenase precursor |
| Synonyms | 1200014D15Rik, Dimethylglycine Dehydrogenase, dimethylglycine dehydrogenase precursor, DMGDHD, ME2GLYDH |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Dmgdh often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- FAD dependent oxidoreductase central domain
- flavin adenine dinucleotide binding
- Glycine cleavage T-protein C-terminal barrel domain
- Aminomethyltransferase folate-binding domain
- oxidoreductase acting on the CH-NH group of donors with a flavin as acceptor
- folic acid binding
- glycine cleavage system aminomethyltransferase GcvT
- dimethylglycine dehydrogenase
- FAD dependent oxidoreductase
- enzyme
- sarcosine oxidase, monomeric form
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Mitochondria
- mitochondrial matrix
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Dmgdh gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- choline catabolic process
- choline metabolic process
- betaine catabolic process
Cellular Component
Where in the cell the gene product is active
- mitochondrial matrix
- cytoplasm
- mitochondrion
Molecular Function
What the gene product does at the molecular level
- RNA binding
- electron carrier activity
- dimethylglycine dehydrogenase activity