Dmgdh Gene Summary [Rat]
Enables dimethylglycine dehydrogenase activity; flavin adenine dinucleotide binding activity; and folic acid binding activity. Involved in tetrahydrofolate interconversion. Predicted to be active in mitochondrial matrix. Human ortholog(s) of this gene implicated in dimethylglycine dehydrogenase deficiency. Orthologous to human DMGDH (dimethylglycine dehydrogenase). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Dmgdh |
| Official Name | dimethylglycine dehydrogenase [Source:RGD Symbol;Acc:620453] |
| Ensembl ID | ENSRNOG00000023588 |
| Bio databases IDs | |
| Aliases | dimethylglycine dehydrogenase |
| Synonyms | 1200014D15Rik, Dimethylglycine Dehydrogenase, dimethylglycine dehydrogenase precursor, DMGDHD, ME2GLYDH |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Dmgdh often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- FAD dependent oxidoreductase central domain
- flavin adenine dinucleotide binding
- Glycine cleavage T-protein C-terminal barrel domain
- Aminomethyltransferase folate-binding domain
- oxidoreductase acting on the CH-NH group of donors with a flavin as acceptor
- folic acid binding
- glycine cleavage system aminomethyltransferase GcvT
- dimethylglycine dehydrogenase
- FAD dependent oxidoreductase
- enzyme
- sarcosine oxidase, monomeric form
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Mitochondria
- mitochondrial matrix
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Dmgdh gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- choline catabolic process
- choline metabolic process
- betaine catabolic process
Cellular Component
Where in the cell the gene product is active
- mitochondrial matrix
- cytoplasm
- mitochondrion
Molecular Function
What the gene product does at the molecular level
- RNA binding
- electron carrier activity
- dimethylglycine dehydrogenase activity