Armc5 Gene Summary [Mouse]
Acts upstream of or within several processes, including T cell activation; adrenal cortex development; and defense response to virus. Located in membrane. Is expressed in thymus primordium. Human ortholog(s) of this gene implicated in ACTH-independent macronodular adrenal hyperplasia 2. Orthologous to human ARMC5 (armadillo repeat containing 5). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Processed Transcript |
| Official Symbol | Armc5 |
| Official Name | armadillo repeat containing 5 [Source:MGI Symbol;Acc:MGI:2384586] |
| Ensembl ID | ENSMUSG00000042178 |
| Bio databases IDs | |
| Aliases | armadillo repeat containing 5 |
| Synonyms | AIMAH2, armadillo repeat containing 5 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Armc5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- BTB_POZ
- protein binding activity, bridging
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- ACTH-independent macronodular adrenal hyperplasia type 2
- Cushing syndrome due to adrenocorticotropin-independent bilateral macronodular adrenal hyperplasia
regulated by
- vaccinia virus
role in cell
- expression in
- proliferation
- differentiation
- degradation in
- tanespimycin sensitivity
- hematopoiesis
- pladienolide B sensitivity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
- focal adhesions
- Nucleus
- cytosol
- nucleoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Armc5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- in utero embryonic development
- T cell proliferation
- adrenal cortex development
- defense response to virus
- CD4-positive, alpha-beta T cell differentiation
- anatomical structure morphogenesis
- mesoderm formation
- regulation of steroid biosynthetic process
Cellular Component
Where in the cell the gene product is active
- focal adhesion
- cytoplasm
- membrane
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding