Scd2 Gene Summary [Mouse]
Enables palmitoyl-CoA 9-desaturase activity and stearoyl-CoA 9-desaturase activity. Acts upstream of or within monounsaturated fatty acid biosynthetic process. Located in endoplasmic reticulum. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Orthologous to human SCD (stearoyl-CoA desaturase). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Scd2 |
| Official Name | stearoyl-Coenzyme A desaturase 2 [Source:MGI Symbol;Acc:MGI:98240] |
| Ensembl ID | ENSMUSG00000025203 |
| Bio databases IDs | |
| Aliases | stearoyl-Coenzyme A desaturase 2 |
| Synonyms | Mir5114, Scd, Stearoyl-coa desaturase 2, stearoyl-Coenzyme A desaturase 2, swty |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Scd2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- stearoyl-CoA 9-desaturase
- Membrane-FADS-like
- oxidoreductase
- Fatty acid desaturase
- CoA desaturase
- iron ion binding
- enzyme
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- Huntington disease
- hepatocellular carcinoma
- liver cancer
- dermatological disorder
- diabetes mellitus
- aortic arch calcification
- hyperkeratosis
role in cell
- expression in
- phosphorylation in
- abnormal morphology
- production in
- adipogenesis in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
- Endoplasmic Reticulum
- endoplasmic reticulum membrane
- nucleoli