Espl1 Gene Summary [Mouse]
Enables cysteine-type peptidase activity. Acts upstream of or within homologous chromosome segregation; meiotic spindle organization; and mitotic sister chromatid segregation. Predicted to be active in cytoplasm; microtubule cytoskeleton; and nucleus. Is expressed in several structures, including alimentary system; brain; genitourinary system; integumental system; and respiratory system. Used to study breast cancer. Orthologous to human ESPL1 (extra spindle pole bodies like 1, separase). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Espl1 |
| Official Name | extra spindle pole bodies 1, separase [Source:MGI Symbol;Acc:MGI:2146156] |
| Ensembl ID | ENSMUSG00000058290 |
| Bio databases IDs | |
| Aliases | extra spindle pole bodies 1, separase |
| Synonyms | CERP, ESP1, extra spindle pole bodies 1, separase, extra spindle pole bodies like 1, separase, LOC100912244, LOC103690081, PRCE, SEPA, SEPARASE, SSE |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Espl1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- cysteine-type peptidase
- peptidase
- active site
- Peptidase family C50
- protein binding
Pathways
Biological processes and signaling networks where the Espl1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- colon adenocarcinoma
- rectum cancer
- gastric adenocarcinoma
- lung cancer
- cancer
- chromophobe renal cell carcinoma
- chromophobe renal cancer
- cholangiocarcinoma
- cholangiocarcinoma cancer
- pancreatic adenocarcinoma
role in cell
- growth
- apoptosis
- quantity
- proliferation
- dispersal
- formation
- segregation
- aneuploidy
- molecular cleavage in
- polyploidization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- centrosome
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Espl1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- establishment of mitotic spindle localization
- cytokinesis after mitosis
- proteolysis
- apoptotic process
- homologous chromosome segregation
- mitotic sister chromatid segregation
- positive regulation of mitotic metaphase/anaphase transition
- negative regulation of sister chromatid cohesion
- meiotic chromosome separation
- mitotic sister chromatid separation
- meiotic spindle organization
Cellular Component
Where in the cell the gene product is active
- nucleus
- centrosome
- mitotic spindle
- cytoplasm
- cytosol
Molecular Function
What the gene product does at the molecular level
- protein binding
- catalytic activity
- cysteine-type endopeptidase activity
- cysteine-type peptidase activity