Prdm14 Gene Summary [Mouse]
Enables several functions, including DNA binding activity; histone methyltransferase binding activity; and methyltransferase regulator activity. Involved in germ cell development; positive regulation of flagellated sperm motility; and positive regulation of stem cell population maintenance. Acts upstream of or within several processes, including embryo implantation; inner cell mass cell fate commitment; and negative regulation of macromolecule biosynthetic process. Located in nucleus. Is expressed in several structures, including hemolymphoid system; intestine; liver; lung; and yolk sac. Human ortholog(s) of this gene implicated in lung non-small cell carcinoma. Orthologous to human PRDM14 (PR/SET domain 14). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Prdm14 |
| Official Name | PR domain containing 14 [Source:MGI Symbol;Acc:MGI:3588194] |
| Ensembl ID | ENSMUSG00000042414 |
| Bio databases IDs | |
| Aliases | PR domain containing 14 |
| Synonyms | LOC100365184, PFM11, PR domain containing 14, PR/SET domain 14 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Prdm14 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Zinc finger, C2H2 type
- transcription regulator
- SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
- nucleic acid binding
- enzyme binding
- chromatin binding
- enzyme regulator activity
- protein binding
- sequence-specific DNA binding
- DNA binding
- RNA binding
- zinc finger
- double-stranded DNA binding
- Zinc-finger double domain
- SET domain
- SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain superfamily
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- schizophrenia
- breast cancer
- non-insulin-dependent diabetes mellitus
- Alzheimer disease
- major depression
- epithelial cancer
- testicular germ cell tumor
- germ cell neoplasia
- gastric cancer
- testicular carcinoma
regulates
- DNA promoter
- DNA endogenous promoter
- POU5F1
- RNA polymerase II
role in cell
- growth
- cell death
- morphogenesis
- maintenance
- specification
- fertilization
- lack
- development
- cellular reprogramming
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- intracellular membrane-bounded organelle
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Prdm14 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- germ cell development
- negative regulation of fibroblast growth factor receptor signaling pathway
- cell morphogenesis
- fibroblast growth factor receptor signaling pathway
- fertilization
- embryo implantation
- regulation of gene expression, epigenetic
- regulation of transcription from RNA polymerase II promoter
- negative regulation of transcription from RNA polymerase II promoter
- homeostasis of number of cells within a tissue
- germ-line stem cell maintenance
- inner cell mass cell fate commitment
- cell fate specification
- methylation
Cellular Component
Where in the cell the gene product is active
- nucleus
- intracellular membrane-bounded organelle
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- chromatin DNA binding
- protein binding
- RNA binding
- metal ion binding
- RNA polymerase II regulatory region sequence-specific DNA binding
- methyltransferase activity