Tcf7 Gene Summary [Mouse]

This gene encodes a transcription factor which is a member of the T-cell specific transcription factor family. The encoded protein is distinct from the hepatic transcription factor, transcription factor 1, which is also referred to by the symbol Tcf1. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Sep 2015]

Details

Type
Protein Coding
Official Symbol
Tcf7
Official Name
transcription factor 7, T cell specific [Source:MGI Symbol;Acc:MGI:98507]
Ensembl ID
ENSMUSG00000000782
Bio databases IDs NCBI: 21414 Ensembl: ENSMUSG00000000782
Aliases transcription factor 7, T cell specific
Synonyms AI465550, TCF-1, transcription factor 7, transcription factor 7, T cell specific
Species
Mouse, Mus musculus
OrthologiesHumanRat

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Tcf7 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • beta-catenin binding domain
  • transcription regulator
  • DNA binding domain
  • nucleic acid binding
  • beta-catenin binding
  • high mobility group (HMG)-box domain superfamily
  • protein binding
  • sequence-specific DNA binding
  • DNA binding
  • RNA polymerase II transcription regulatory region sequence-specific binding transcriptional repressor activity
  • double-stranded DNA binding
  • N-terminal CTNNB1 binding
  • HMG (high mobility group) box
  • HMG-box domain
  • high mobility group
  • transcription factor activity

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
  • neoplasia
  • epithelial cancer
  • epithelial neoplasia
  • cancer
  • benign neoplasia
  • metastasis
  • adenoma formation
  • liver cancer
  • lymphomagenesis
  • hematologic cancer
regulated by
role in cell
  • binding in
  • survival
  • proliferation
  • expression in
  • apoptosis
  • transactivation in
  • production in
  • downregulation in
  • activation in
  • differentiation

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Nucleus
  • Cytoplasm
  • nucleoplasm
  • nuclear bodies
  • chromatin

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the mouse Tcf7 gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • immune response
  • negative regulation of transcription, DNA-dependent
  • gamma-delta T cell differentiation
  • cellular response to interleukin-4
  • canonical Wnt receptor signaling pathway
  • regulation of transcription, DNA-dependent
  • regulation of gamma-delta T cell differentiation
  • regulation of transcription from RNA polymerase II promoter

Cellular Component

Where in the cell the gene product is active
  • nucleus
  • nuclear body
  • chromatin
  • nucleoplasm

Molecular Function

What the gene product does at the molecular level
  • protein binding
  • RNA polymerase II core promoter proximal region sequence-specific DNA binding
  • transcription regulatory region sequence-specific DNA binding
  • sequence-specific DNA binding bacterial-type RNA polymerase transcription factor activity involved in negative regulation of transcription
  • beta-catenin binding
  • sequence-specific DNA binding RNA polymerase II transcription factor activity

Gene-Specific Assays for Results You Can Trust

Streamline your workflow with assays designed for this gene. Our targeted dPCR and qPCR assays help you generate meaningful data – efficiently and accurately.