Rad51d Gene Summary [Mouse]

This gene belongs to the Rad51 gene family whose products play a major role in homologous recombination and DNA repair. The encoded protein interacts with other proteins of this family, including Rad51b, Rad51c and Xrcc2, and plays an essential role in both DNA repair and telomere maintenance. In humans, germline mutations in this gene may be associated with predisposition to ovarian cancer. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, May 2013]

Details

Type
Nonsense Mediated Decay
Official Symbol
Rad51d
Official Name
RAD51 paralog D [Source:MGI Symbol;Acc:MGI:1261809]
Ensembl ID
ENSMUSG00000018841
Bio databases IDs NCBI: 19364 Ensembl: ENSMUSG00000018841
Aliases RAD51 paralog D
Synonyms BROVCA4, R51H3, RAD51L3, RAD51 paralog D, TRAD, Trad-d5
Species
Mouse, Mus musculus
OrthologiesHumanRat

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Rad51d often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • gamma-tubulin binding
  • DNA repair and recombination protein RadA
  • single-stranded DNA binding
  • DNA secondary structure binding
  • Rad51
  • enzyme
  • protein binding
  • DNA dependent ATPase
  • P-loop containing Nucleoside Triphosphate Hydrolases
  • DNA binding
  • ATPases associated with a variety of cellular activities
  • AAA domain

Pathways

Biological processes and signaling networks where the Rad51d gene in mouse plays a role, providing insight into its function and relevance in health or disease.

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
  • cancer
  • hereditary cancer-predisposing syndrome
  • susceptibility to familial breast-ovarian cancer type 4
  • edema
  • breast or ovarian cancer
  • epithelial cancer
  • gastric cancer
  • ovarian cancer
  • breast carcinoma
  • breast cancer
regulated by
regulates
  • double-stranded DNA
  • BLM
role in cell
  • cell death
  • quantity
  • growth
  • survival
  • organization
  • cell cycle progression
  • maintenance
  • DNA damage response
  • sensitivity
  • stabilization

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Nucleus
  • nuclear fraction
  • centrosome
  • nuclear foci
  • nucleoplasm
  • telomeres
  • replication fork
  • chromosomal bouquet
  • plasma

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the mouse Rad51d gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • DNA repair
  • reciprocal meiotic recombination
  • double-strand break repair via homologous recombination
  • telomere maintenance
  • telomere maintenance via recombination
  • regulation of cell cycle
  • strand invasion

Cellular Component

Where in the cell the gene product is active
  • Rad51B-Rad51C-Rad51D-XRCC2 complex
  • replication fork
  • chromosome, telomeric region
  • nucleus
  • centrosome
  • cytoplasm
  • nucleoplasm

Molecular Function

What the gene product does at the molecular level
  • ATPase activity
  • DNA binding
  • ATP binding
  • DNA-dependent ATPase activity
  • protein binding
  • gamma-tubulin binding
  • four-way junction DNA binding
  • single-stranded DNA binding

Gene-Specific Assays for Results You Can Trust

Streamline your workflow with assays designed for this gene. Our targeted dPCR and qPCR assays help you generate meaningful data – efficiently and accurately.