Mios Gene Summary [Mouse]
Predicted to enable zinc ion binding activity. Involved in central nervous system myelin formation; oligodendrocyte progenitor proliferation; and positive regulation of TORC1 signaling. Predicted to be located in several cellular components, including cytosol; lysosomal membrane; and nucleoplasm. Predicted to be part of GATOR2 complex. Predicted to be active in cytoplasm. Is expressed in retina. Orthologous to human MIOS (meiosis regulator for oocyte development). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Mios |
| Official Name | meiosis regulator for oocyte development [Source:MGI Symbol;Acc:MGI:2182066] |
| Ensembl ID | ENSMUSG00000042447 |
| Bio databases IDs | |
| Aliases | meiosis regulator for oocyte development |
| Synonyms | meiosis regulator for oocyte development, MIO, Missing oocyte, meiosis regulator, homolog, RGD1308432, Sea4, Yulink |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Mios often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RING/Ubox like zinc-binding domain
- RING finger (Really Interesting New Gene) domain and U-box domain superfamily
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cell junction
- cytosol
- lysosome membrane
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Mios gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- oligodendrocyte differentiation
- protein complex localization
- cellular response to nutrient levels
- cellular response to amino acid starvation
- central nervous system myelin formation
- oligodendrocyte progenitor proliferation
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- cytosol
- cell junction
- lysosomal membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- metal ion binding