Sesn2 Gene Summary [Mouse]
Enables GDP-dissociation inhibitor activity and PH domain binding activity. Involved in several processes, including DNA damage response, signal transduction by p53 class mediator; negative regulation of TORC1 signaling; and negative regulation of translation in response to endoplasmic reticulum stress. Acts upstream of or within several processes, including D-glucose import; positive regulation of metabolic process; and regulation of intracellular signal transduction. Part of TORC2 complex and nucleotide-activated protein kinase complex. Is expressed in central nervous system; heart; and retina. Orthologous to human SESN2 (sestrin 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Sesn2 |
| Official Name | sestrin 2 [Source:MGI Symbol;Acc:MGI:2651874] |
| Ensembl ID | ENSMUSG00000028893 |
| Bio databases IDs | |
| Aliases | sestrin 2 |
| Synonyms | HI95, RGD1566319, SES2, SEST2, Sestrin 2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Sesn2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- PA26 p53-induced protein (sestrin)
- enzyme
- uncharacterized peroxidase-related enzyme
- antioxidant enzyme
- protein binding
- PH-domain binding
- amino acid binding
- sulfur group oxidoreductase
- peroxidase
- GDP-dissociation inhibitor
- binding protein
- alkylhydroperoxidase AhpD family core domain
- guanine nucleotide dissociation inhibitor domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- psoriasis
- streptozotocin-induced diabetes
- diabetic nephropathy
- mitochondrial disorder
- pulmonary emphysema
regulated by
- methotrexate
- brefeldin A
- streptozocin
- SIRT1 inhibitor III
- TP53
- doxorubicin
- leucine
- metformin
- sirolimus
- mitomycin C
role in cell
- expression in
- cell death
- accumulation in
- apoptosis
- proliferation
- activation in
- phosphorylation in
- signaling in
- upregulation in
- production in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- cytosol
- lysosome membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Sesn2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of protein localization to nucleus
- positive regulation of macroautophagy
- cellular response to amino acid starvation
- mitochondrial DNA metabolic process
- glucose import
- regulation of gluconeogenesis
- cellular response to glucose starvation
- reactive oxygen species metabolic process
- cellular response to amino acid stimulus
- response to glucose stimulus
- fatty acid beta-oxidation
- response to insulin stimulus
- cellular response to leucine
- regulation of protein phosphorylation
- negative regulation of cell growth
- glucose homeostasis
- DNA damage response, signal transduction by p53 class mediator
- cellular response to oxidative stress
- triglyceride homeostasis
- positive regulation of protein kinase B signaling cascade
Cellular Component
Where in the cell the gene product is active
- nucleus
- TORC2 complex
- cytoplasm
- mitochondrion
- cytosol
- lysosomal membrane
- AMP-activated protein kinase complex
Molecular Function
What the gene product does at the molecular level
- leucine binding
- peroxidase activity
- protein binding
- GDP-dissociation inhibitor activity
- sulfiredoxin activity
- oxidoreductase activity, acting on peroxide as acceptor
- PH domain binding