Wdr59 Gene Summary [Mouse]
Predicted to enable signaling adaptor activity. Predicted to be involved in cellular response to amino acid starvation and positive regulation of TORC1 signaling. Predicted to act upstream of or within positive regulation of protein kinase activity and protein localization to plasma membrane. Predicted to be located in cytosol and lysosomal membrane. Predicted to be part of GATOR2 complex. Predicted to be active in vacuolar membrane. Is expressed in ductus deferens; metanephros; prostate gland; testis; and thyroid gland. Orthologous to human WDR59 (WD repeat domain 59). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Wdr59 |
| Official Name | WD repeat domain 59 [Source:MGI Symbol;Acc:MGI:2442115] |
| Ensembl ID | ENSMUSG00000031959 |
| Bio databases IDs | |
| Aliases | WD repeat domain 59 |
| Synonyms | 5430401O09Rik, CDW12, FP977, LOC100364372, p90-120, WD repeat domain 59 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Wdr59 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- WD40 repeats
- RING/Ubox like zinc-binding domain
- RING finger (Really Interesting New Gene) domain and U-box domain superfamily
- WD domain, G-beta repeat
- RWD domain
- protein binding
- transporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- intracellular membrane-bounded organelle
- cytosol
- lysosome membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Wdr59 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cellular response to nutrient levels
- cellular response to amino acid starvation
Cellular Component
Where in the cell the gene product is active
- Seh1-associated complex
- intracellular membrane-bounded organelle
- cytosol
- vacuolar membrane
- lysosomal membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- metal ion binding
- signaling adaptor activity