Tfap2e Gene Summary [Mouse]
Enables DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and identical protein binding activity. Acts upstream of or within positive regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in several structures, including brain; early conceptus; neural ectoderm; ovary; and vomeronasal organ. Orthologous to human TFAP2E (transcription factor AP-2 epsilon). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tfap2e |
| Official Name | transcription factor AP-2, epsilon [Source:MGI Symbol;Acc:MGI:2679630] |
| Ensembl ID | ENSMUSG00000042477 |
| Bio databases IDs | |
| Aliases | transcription factor AP-2, epsilon |
| Synonyms | AP-2e, AP-2epsilon, RGD1563297, Tcfap2e, transcription factor AP-2 epsilon, transcription factor AP-2, epsilon, transcription factor AP-2 ε, transcription factor AP-2, ε |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Tfap2e often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- transcription regulator
- nucleic acid binding
- double-stranded DNA binding
- Transcription factor AP-2
- protein binding
- sequence-specific DNA binding
- identical protein binding
- DNA binding
Pathways
Biological processes and signaling networks where the Tfap2e gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Tfap2e gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- anatomical structure development
- positive regulation of transcription from RNA polymerase II promoter
- regulation of cell proliferation
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- chromatin
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- RNA polymerase II regulatory region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
- sequence-specific DNA binding RNA polymerase II transcription factor activity