Smc5 Gene Summary [Mouse]
Predicted to enable DNA secondary structure binding activity and single-stranded DNA binding activity. Acts upstream of or within several processes, including internal peptidyl-lysine acetylation; mitotic cell cycle phase transition; and protein localization to chromosome, centromeric region. Located in PML body; chromosome; and cytoplasm. Part of Smc5-Smc6 complex. Is expressed in ovary; secondary spermatocyte; and testis. Human ortholog(s) of this gene implicated in mosaic variegated aneuploidy syndrome. Orthologous to human SMC5 (structural maintenance of chromosomes 5). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Smc5 |
| Official Name | structural maintenance of chromosomes 5 [Source:MGI Symbol;Acc:MGI:2385088] |
| Ensembl ID | ENSMUSG00000024943 |
| Bio databases IDs | |
| Aliases | structural maintenance of chromosomes 5 |
| Synonyms | ATELS2, mKIAA0594, MLZ-453, mSmc5, SMC5L1, structural maintenance of chromosomes 5 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Smc5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- chromosome segregation protein SMC, common bacterial type
- RecF/RecN/SMC N terminal domain
- chromosome segregation protein SMC, primarily archaeal type
- DNA secondary structure binding
- Growth-arrest specific micro-tubule binding
- protein binding
- AAA domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Atelis syndrome type 2
- primordial dwarfism, chromosomal instability and insulin resistance
role in cell
- survival
- differentiation
- maintenance
- segregation
- DNA damage response
- clustering
- distribution in
- segregation in
- processing in
- clustering in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- cell junction
- Cytoplasm
- chromosome
- interchromatin granules
- nucleoplasm
- nuclear speckles
- PML nuclear bodies
- centromeres
- telomeres
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Smc5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of maintenance of mitotic sister chromatid cohesion
- stem cell maintenance
- protein sumoylation
- chromosome condensation
- cellular senescence
- double-strand break repair via homologous recombination
- chromosome segregation
- telomere maintenance via recombination
- response to DNA damage stimulus
- double-strand break repair via nonhomologous end joining
- cell division
- positive regulation of chromosome segregation
- protein localization to chromosome, centromeric region
- regulation of telomere maintenance
Cellular Component
Where in the cell the gene product is active
- site of double-strand break
- PML body
- sex chromosome
- nuclear speck
- interchromatin granule
- chromosome, centromeric region
- nucleoplasm
- nucleus
- chromosome, telomeric region
- cytoplasm
- Smc5-Smc6 complex
- cell junction
Molecular Function
What the gene product does at the molecular level
- ATPase activity
- ATP binding
- protein binding
- DNA secondary structure binding
- single-stranded DNA binding