Il18 Gene Summary [Mouse]
Enables cytokine activity. Involved in several processes, including cholesterol homeostasis; establishment of skin barrier; and positive regulation of cell differentiation. Acts upstream of or within several processes, including natural killer cell mediated cytotoxicity; negative regulation of myoblast differentiation; and positive regulation of type II interferon production. Is active in extracellular space. Is expressed in extraembryonic component; gut; lymphatic system; reproductive system; and trunk. Used to study atopic dermatitis. Human ortholog(s) of this gene implicated in several diseases, including Kawasaki disease; allergic rhinitis; autoimmune disease (multiple); biliary atresia; and hepatitis B. Orthologous to human IL18 (interleukin 18). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Il18 |
| Official Name | interleukin 18 [Source:MGI Symbol;Acc:MGI:107936] |
| Ensembl ID | ENSMUSG00000039217 |
| Bio databases IDs | |
| Aliases | interleukin 18 |
| Synonyms | IGIF, IL1F4, IL-1g, IL-1 gamma, IL-1 γ, interferon-gamma-inducing factor, interferon-γ-inducing factor, interleukin 18 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Il18 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- receptor agonist activity
- protein binding
- interleukin-18 receptor binding
- cytokine
- beta-trefoil domain found in the interleukin-1 (IL-1) family of cytokines
Pathways
Biological processes and signaling networks where the Il18 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- Acute Phase Response Signaling
- Atherosclerosis Signaling
- Cholecystokinin/Gastrin-mediated Signaling
- Crosstalk between Dendritic Cells and Natural Killer Cells
- Dendritic Cell Maturation
- FXR/RXR Activation
- Graft-versus-Host Disease Signaling
- IL-6 Signaling
- Inflammasome pathway
- LPS/IL-1 Mediated Inhibition of RXR Function
- LXR/RXR Activation
- NF-κB Signaling
- p38 MAPK Signaling
- PPAR Signaling
- Role of Cytokines in Mediating Communication between Immune Cells
- Role of Hypercytokinemia/hyperchemokinemia in the Pathogenesis of Influenza
- Role of Pattern Recognition Receptors in Recognition of Bacteria and Viruses
- Role of PKR in Interferon Induction and Antiviral Response
- T Helper Cell Differentiation
- Th1 Pathway
- Toll-like Receptor Signaling
- TREM1 Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- liver cancer
- liver neoplasia
- digestive system cancer
- abdominal cancer
- cancer
- epithelial cancer
- epithelial neoplasia
- neoplasia
- systemic lupus erythematosus
- hypernociception
role in cell
- migration
- expression in
- phosphorylation in
- proliferation
- binding in
- production in
- apoptosis
- survival
- quantity
- cell death
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Cytoplasm
- cell surface
- Nucleus
- Plasma Membrane
- cytosol
- apical membrane
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Il18 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell proliferation
- neutrophil activation
- positive regulation of tyrosine phosphorylation of STAT protein
- positive regulation of transcription from RNA polymerase II promoter
- cholesterol homeostasis
- positive regulation of NF-kappaB transcription factor activity
- establishment of skin barrier
- positive regulation of smooth muscle cell proliferation
- inflammatory response
- positive regulation of granulocyte macrophage colony-stimulating factor production
- angiogenesis
- positive regulation of NK T cell proliferation
- positive regulation of interferon-gamma production
- positive regulation of tissue remodeling
- positive regulation of interleukin-17 production
- positive regulation of T-helper 1 cell cytokine production
- natural killer cell activation
- positive regulation of chemokine production
- triglyceride homeostasis
- interleukin-18-mediated signaling pathway
- defense response to Gram-positive bacterium
- positive regulation of inflammatory response
- T-helper 1 type immune response
- cell-cell signaling
- positive regulation of T-helper 2 cell differentiation
- natural killer cell mediated cytotoxicity
- positive regulation of activated T cell proliferation
- type 2 immune response
- positive regulation of interleukin-13 production
- negative regulation of myoblast differentiation
- positive regulation of natural killer cell proliferation
- sleep
- positive regulation of macrophage derived foam cell differentiation
- regulation of cell adhesion
- positive regulation of protein kinase B signaling cascade
Cellular Component
Where in the cell the gene product is active
- extracellular space
- cytosol
- extracellular region
Molecular Function
What the gene product does at the molecular level
- protein binding
- cytokine activity
- interleukin-18 receptor binding