Qrfp Gene Summary [Mouse]

This gene encodes a preproprotein that is proteolytically processed to generate multiple protein products. The encoded products are members of the RFamide family of neuropeptides, characterized by their common protein C-terminus consisting of an arginine (R) and an amidated phenylalanine (F). These products include the neuropeptides QRFP-26 (26RFa) and the N-terminally extended form, QRFP-43 (43RFa). Both of these neuropeptides bind to the pyroglutamylated RFamide peptide receptor (QRFPR) and may regulate blood pressure, reproduction and food intake. [provided by RefSeq, Sep 2015]

Details

Type
Protein Coding
Official Symbol
Qrfp
Official Name
pyroglutamylated RFamide peptide [Source:MGI Symbol;Acc:MGI:3630329]
Ensembl ID
ENSMUSG00000043102
Bio databases IDs NCBI: 227717 Ensembl: ENSMUSG00000043102
Aliases pyroglutamylated RFamide peptide
Synonyms 26RFa, NEWGENE 735020, P518, pyroglutamylated RFamide peptide
Species
Mouse, Mus musculus
OrthologiesHumanRat

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Qrfp often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • G-protein-coupled receptor binding
  • neuropeptide hormone
  • Orexigenic neuropeptide Qrfp/P518
  • RF-amide motif

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
  • obesity
regulated by
  • lipopolysaccharide
  • LEP
  • neurons
  • LEPR
regulates
role in cell
  • expression in
  • activation
  • accumulation in
  • differentiation
  • uptake by
  • lipolysis in

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Extracellular Space
  • membrane fraction

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the mouse Qrfp gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • grooming behavior
  • neuropeptide signaling pathway
  • locomotory behavior
  • positive regulation of blood pressure
  • regulation of feeding behavior
  • behavior

Cellular Component

Where in the cell the gene product is active
  • extracellular region

Molecular Function

What the gene product does at the molecular level
  • neuropeptide hormone activity
  • orexigenic neuropeptide QRFP receptor binding

Gene-Specific Assays for Results You Can Trust

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