Pigv Gene Summary [Mouse]

Predicted to enable mannosyltransferase activity. Predicted to be involved in GPI anchor biosynthetic process. Predicted to be part of mannosyltransferase complex. Predicted to be active in endoplasmic reticulum membrane. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in hyperphosphatasia with impaired intellectual development syndrome 1. Orthologous to human PIGV (phosphatidylinositol glycan anchor biosynthesis class V). [provided by Alliance of Genome Resources, Apr 2025]

Details

Type
Protein Coding
Official Symbol
Pigv
Official Name
phosphatidylinositol glycan anchor biosynthesis, class V [Source:MGI Symbol;Acc:MGI:2442480]
Ensembl ID
ENSMUSG00000043257
Bio databases IDs NCBI: 230801 Ensembl: ENSMUSG00000043257
Aliases phosphatidylinositol glycan anchor biosynthesis, class V
Synonyms B330013B03, D430024F16Rik, GPI-MT-II, HPMRS1, phosphatidylinositol glycan anchor biosynthesis class V, phosphatidylinositol glycan anchor biosynthesis, class V, RGD1309526
Species
Mouse, Mus musculus
OrthologiesHumanRat

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Pigv often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • alpha-1,6-mannosyltransferase
  • mannosyltransferase
  • enzyme
  • protein binding
  • glycolipid mannosyltransferase
  • dolichyl-phosphate-mannose-protein mannosyltransferase

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
regulated by
  • mir-449 (includes others)
disease
  • hyperphosphatasia with mental retardation syndrome type 1
  • organismal death
  • hereditary disorder
role in cell
  • development
  • motility
  • invasiveness

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Cytoplasm
  • endoplasmic reticulum membrane

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the mouse Pigv gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • GPI anchor biosynthetic process
  • preassembly of GPI anchor in ER membrane

Cellular Component

Where in the cell the gene product is active
  • endoplasmic reticulum membrane
  • membrane
  • mannosyltransferase complex

Molecular Function

What the gene product does at the molecular level
  • protein binding
  • mannosyltransferase activity
  • alpha-1,6-mannosyltransferase activity
  • glycolipid mannosyltransferase activity

Gene-Specific Assays for Results You Can Trust

Streamline your workflow with assays designed for this gene. Our targeted dPCR and qPCR assays help you generate meaningful data – efficiently and accurately.