Mdga1 Gene Summary [Mouse]
Involved in neuron migration. Acts upstream of or within several processes, including dopamine metabolic process; prepulse inhibition; and synapse assembly. Is active in axon; cell surface; and dendrite. Is expressed in central nervous system and dorsal root ganglion. Orthologous to human MDGA1 (MAM domain containing glycosylphosphatidylinositol anchor 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Mdga1 |
| Official Name | MAM domain containing glycosylphosphatidylinositol anchor 1 [Source:MGI Symbol;Acc:MGI:1922012] |
| Ensembl ID | ENSMUSG00000043557 |
| Bio databases IDs | |
| Aliases | MAM domain containing glycosylphosphatidylinositol anchor 1 |
| Synonyms | 1200011I03Rik, GPIM, MAMDC3, MAM domain containing glycosylphosphatidylinositol anchor 1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Mdga1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- MAM protein domain
- Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
- CD19_double_Ig
- immunoglobulin domain
- Immunoglobulin like
- Immunoglobulin I-set domain
- protein binding
- MAM domain, meprin/A5/mu
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- major depression
- coronary aneurysm
- restless legs syndrome
- insomnia
- side effect
- conotruncal heart malformations
role in cell
- binding in
- assembly
- differentiation
- adhesion
- migration
- density
- maturation
- presynaptic differentiation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- glutaminergic synapse
- cell surface
- Extracellular Space
- Golgi Apparatus
- synaptic membrane
- synapse
- membrane rafts
- axons
- dendrites
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Mdga1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- neuron migration
- spinal cord association neuron differentiation
- nervous system development
- cerebral cortex radially oriented cell migration
- brain development
Cellular Component
Where in the cell the gene product is active
- extracellular space
- Golgi apparatus
- extracellular region
- plasma membrane