Nlgn2 Gene Summary [Mouse]
Enables cell adhesion molecule binding activity; identical protein binding activity; and neurexin family protein binding activity. Involved in several processes, including modulation of chemical synaptic transmission; regulation of signal transduction; and synapse organization. Acts upstream of or within several processes, including protein localization to cell surface; regulation of respiratory gaseous exchange by nervous system process; and synapse organization. Located in synapse. Is active in several cellular components, including dopaminergic synapse; glycinergic synapse; and postsynaptic specialization membrane. Is expressed in brain; brainstem; cerebral cortex; and hippocampus. Used to study schizophrenia. Orthologous to human NLGN2 (neuroligin 2). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Nlgn2 |
| Official Name | neuroligin 2 [Source:MGI Symbol;Acc:MGI:2681835] |
| Ensembl ID | ENSMUSG00000051790 |
| Bio databases IDs | |
| Aliases | neuroligin 2 |
| Synonyms | Neuroligin-2, NL2, NLG2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Nlgn2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- Carboxylesterase family
- cytoplasmic domain
- alpha/beta hydrolases
- cell adhesion molecule binding
- neurexin binding
- protein binding
- identical protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- major depression
- lung adenocarcinoma
- lung adenocarcinoma formation
- uterine leiomyoma
- leiomyomatosis
- breast cancer
- squamous-cell carcinoma
- squamous cell cancer
- septic shock
- glioblastoma
role in cell
- proliferation
- activity
- function in
- morphogenesis
- differentiation
- organization
- presynaptic differentiation
- assembly
- cell-cell adhesion
- function
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- cellular membrane
- postsynaptic membrane
- synaptic membrane
- synaptic vesicles
- synaptosomes
- synapse
- perikaryon
- axons
- dendrites
- inhibitory synapse
- ribbon synapse
- excitatory synapses
- dendritic shafts
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Nlgn2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein localization at cell surface
- locomotory exploration behavior
- positive regulation of synaptic transmission, GABAergic
- positive regulation of cell proliferation
- jump response
- neuron cell-cell adhesion
- regulation of respiratory gaseous exchange by neurological system process
- positive regulation of inhibitory postsynaptic membrane potential
- postsynaptic membrane assembly
- synaptic vesicle endocytosis
- thigmotaxis
- presynaptic membrane assembly
- regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity
- positive regulation of synaptic transmission, glutamatergic
- protein localization to synapse
- positive regulation of insulin secretion
- positive regulation of synapse assembly
- social behavior
- synapse organization
- synaptic transmission
- positive regulation of dendritic spine development
- positive regulation of synaptic vesicle clustering
- cell-cell junction maintenance
- synapse assembly
- terminal button organization
- gephyrin clustering
- postsynaptic density protein 95 clustering
- sensory perception of pain
- regulation of synaptic transmission
- positive regulation of excitatory postsynaptic membrane potential
- neurotransmitter-gated ion channel clustering
- synaptic transmission, GABAergic
- neuromuscular process controlling balance
Cellular Component
Where in the cell the gene product is active
- inhibitory synapse
- presynaptic membrane
- postsynaptic membrane
- dendritic shaft
- membrane
- excitatory synapse
- synapse
- plasma membrane
- cell surface
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- signaling receptor activity
- neurexin family protein binding
- cell adhesion molecule binding