Pars2 Gene Summary [Mouse]
Predicted to enable proline-tRNA ligase activity. Predicted to be involved in prolyl-tRNA aminoacylation. Located in mitochondrion. Is expressed in adrenal gland and gland. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 75. Orthologous to human PARS2 (prolyl-tRNA synthetase 2, mitochondrial). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Pars2 |
| Official Name | prolyl-tRNA synthetase (mitochondrial)(putative) [Source:MGI Symbol;Acc:MGI:2386296] |
| Ensembl ID | ENSMUSG00000043572 |
| Bio databases IDs | |
| Aliases | prolyl-tRNA synthetase (mitochondrial)(putative) |
| Synonyms | DEE75, EIEE75, MT-PRORS, prolyl-tRNA synthetase 2, mitochondrial, prolyl-tRNA synthetase (mitochondrial)(putative), proRS, RGD1305345 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Pars2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- tRNA synthetase class II core domain (G, H, P, S and T)
- HGTP_anticodon
- class_II_aaRS-like_core
- prolyl-tRNA synthetase, family II
- enzyme
- proline-tRNA ligase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Mitochondria
- mitochondrial matrix
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Pars2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- prolyl-tRNA aminoacylation
Cellular Component
Where in the cell the gene product is active
- mitochondrial matrix
- mitochondrion
Molecular Function
What the gene product does at the molecular level
- ATP binding
- identical protein binding
- proline-tRNA ligase activity