Lpcat1 Gene Summary [Mouse]
Enables O-acyltransferase activity. Involved in phospholipid biosynthetic process. Acts upstream of or within several processes, including negative regulation of phosphatidylcholine biosynthetic process; positive regulation of protein catabolic process; and surfactant homeostasis. Located in Golgi apparatus; endoplasmic reticulum; and membrane. Is expressed in several structures, including eye; genitourinary system; lung; nervous system; and vascular system. Orthologous to human LPCAT1 (lysophosphatidylcholine acyltransferase 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Lpcat1 |
| Official Name | lysophosphatidylcholine acyltransferase 1 [Source:MGI Symbol;Acc:MGI:2384812] |
| Ensembl ID | ENSMUSG00000021608 |
| Bio databases IDs | |
| Aliases | lysophosphatidylcholine acyltransferase 1 |
| Synonyms | 2900035H07Rik, AGPAT10, AGPAT9, AYTL2, FLJ12443, LOC100128216, LPCAT, LPLAT8, lysoPAFAT, lysophosphatidylcholine acyltransferase 1, mLPCAT1, PFAAP3, rd11, RGD1311599 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Lpcat1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis
- 1-acylglycerol-3-phosphate O-acyltransferase
- 1-alkenylglycerophosphocholine O-acyltransferase
- EF-hand domain pair
- 2-acylglycerol-3-phosphate O-acyltransferase
- 1-acylglycerophosphocholine O-acyltransferase
- EFh
- 1-alkylglycerophosphocholine O-acyltransferase
- enzyme
- Acyltransferase
- 1-alkylglycerophosphocholine O-acetyltransferase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- dextran sodium sulfate-induced colitis
- lung squamous cell carcinoma
- gastric cancer
- squamous cell lung cancer
- head and neck squamous cell carcinoma
- pancreatic adenocarcinoma
- cutaneous melanoma
- glioblastoma cancer
- glioma formation
- esophageal carcinoma
role in cell
- expression in
- migration
- production in
- cell death
- phosphorylation in
- invasion by
- degradation in
- ferroptosis
- synthesis in
- saturation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
- Plasma Membrane
- Golgi Apparatus
- Endoplasmic Reticulum
- secretory granule membrane
- lipid droplets
- endoplasmic reticulum membrane
- microsome
- lysosome membrane
- inner nuclear membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Lpcat1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- phosphatidylcholine acyl-chain remodeling
- retina development in camera-type eye
- protein catabolic process
- phospholipid biosynthetic process
- positive regulation of protein catabolic process
- phosphatidylglycerol acyl-chain remodeling
- phosphatidylcholine biosynthetic process
- surfactant homeostasis
- phosphatidic acid biosynthetic process
- negative regulation of phosphatidylcholine biosynthetic process
Cellular Component
Where in the cell the gene product is active
- lipid particle
- endoplasmic reticulum membrane
- membrane
- Golgi membrane
- endoplasmic reticulum
- Golgi apparatus
- azurophil granule membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- 1-acylglycerol-3-phosphate O-acyltransferase activity
- 1-acylglycerophosphocholine O-acyltransferase activity
- lysophosphatidic acid acyltransferase activity
- calcium ion binding
- 2-acylglycerol-3-phosphate O-acyltransferase activity
- 1-alkenylglycerophosphocholine O-acyltransferase activity
- 1-alkylglycerophosphocholine O-acetyltransferase activity
- 1-alkylglycerophosphocholine O-acyltransferase activity