Mgat5b Gene Summary [Mouse]
Enables alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity. Acts upstream of or within protein N-linked glycosylation. Located in Golgi apparatus. Is expressed in nervous system; neural ectoderm; and sensory organ. Orthologous to human MGAT5B (alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase B). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Mgat5b |
| Official Name | mannoside acetylglucosaminyltransferase 5, isoenzyme B [Source:MGI Symbol;Acc:MGI:3606200] |
| Ensembl ID | ENSMUSG00000043857 |
| Bio databases IDs | |
| Aliases | mannoside acetylglucosaminyltransferase 5, isoenzyme B |
| Synonyms | alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase B, C330018B01, GnT-IX, GnT-VB, LOC101928538, mannoside acetylglucosaminyltransferase 5, isoenzyme B, mGnTVB, α-1,6-mannosylglycoprotein 6-β-N-acetylglucosaminyltransferase B |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Mgat5b often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- alpha-1,6-mannosyl-glycoprotein 6-beta-N-acetylglucosaminyltransferase
- Glycosyltransferase family 18
- enzyme
- protein binding
- manganese ion binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- astrocytosis
- demyelination
- endometrium tumor
- hypotension
- pervasive developmental disorder
regulates
- D-glucose
- IgG2b
role in cell
- number
- differentiation
- activation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Golgi Apparatus
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Mgat5b gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein O-linked glycosylation via serine
- protein N-linked glycosylation
Cellular Component
Where in the cell the gene product is active
- Golgi apparatus
- Golgi membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- manganese ion binding
- alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity