Opn5 Gene Summary [Mouse]
Enables 11-cis retinal binding activity and G protein-coupled photoreceptor activity. Involved in entrainment of circadian clock by photoperiod; hyaloid vascular plexus regression; and phototransduction, UV. Predicted to be located in cytoplasm. Predicted to be active in photoreceptor outer segment and plasma membrane. Orthologous to human OPN5 (opsin 5). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Opn5 |
| Official Name | opsin 5 [Source:MGI Symbol;Acc:MGI:2662912] |
| Ensembl ID | ENSMUSG00000043972 |
| Bio databases IDs | |
| Aliases | opsin 5 |
| Synonyms | GPR136, GRP136, IMAGE:4824978, Neuropsin, opsin 5, PGR12, TMEM13 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Opn5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- G-protein coupled photoreceptor
- 7 transmembrane receptor (rhodopsin family)
- 11-cis retinal binding
- seven-transmembrane G protein-coupled receptor superfamily
Pathways
Biological processes and signaling networks where the Opn5 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
- cellular membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Opn5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cellular response to light stimulus
- phototransduction, UV
- cellular response to UV-A
- G-protein coupled receptor signaling pathway
- detection of visible light
- entrainment of circadian clock by photoperiod
- visual perception
- phototransduction
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- 11-cis retinal binding
- G-protein coupled photoreceptor activity