Lmod3 Gene Summary [Mouse]
Predicted to enable actin monomer binding activity and tropomyosin binding activity. Involved in skeletal muscle fiber development. Located in A band. Is expressed in several structures, including ganglia; limb segment; lung; sensory organ; and skeletal musculature. Used to study nemaline myopathy 10. Human ortholog(s) of this gene implicated in nemaline myopathy 10. Orthologous to human LMOD3 (leiomodin 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Lmod3 |
| Official Name | leiomodin 3 (fetal) [Source:MGI Symbol;Acc:MGI:2444169] |
| Ensembl ID | ENSMUSG00000044086 |
| Bio databases IDs | |
| Aliases | leiomodin 3 (fetal) |
| Synonyms | 5430424A14RIK, leiomodin 3, leiomodin 3 (fetal), leiomodin 3 (foetal), LOC687142, LOC687145, NEM10, RGD1564924 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Lmod3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- actin monomer binding
- tropomyosin binding
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- sarcomere
- myofibrils
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Lmod3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- myofibril assembly
- skeletal muscle fiber development
- pointed-end actin filament capping
- muscle contraction
- skeletal muscle thin filament assembly
- actin nucleation
- actin filament organization
- positive regulation of skeletal muscle fiber development
- striated muscle contraction
Cellular Component
Where in the cell the gene product is active
- striated muscle thin filament
- cytoskeleton
- cytoplasm
- M band
- myofibril
Molecular Function
What the gene product does at the molecular level
- protein binding
- tropomyosin binding
- actin monomer binding