Ranbp1 Gene Summary [Mouse]
Predicted to contribute to GTPase activator activity. Acts upstream of or within positive regulation of mitotic centrosome separation and spindle organization. Located in centrosome and cytoplasm. Is expressed in several structures, including branchial arch; cardiovascular system; central nervous system; head mesenchyme; and sensory organ. Orthologous to human RANBP1 (RAN binding protein 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ranbp1 |
| Official Name | RAN binding protein 1 [Source:MGI Symbol;Acc:MGI:96269] |
| Ensembl ID | ENSMUSG00000005732 |
| Bio databases IDs | |
| Aliases | RAN binding protein 1 |
| Synonyms | HTF9A, RAN binding protein 1, Ran-Specific GTPase-Activating |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ranbp1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- nuclear export signal
- GDP-dissociation inhibitor
- enzyme binding
- protein binding
- Pleckstrin homology-like domain
- Ran binding domain
Pathways
Biological processes and signaling networks where the Ranbp1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- breast cancer
- colorectal cancer
- psoriasis
- neoplasia
- metastasis
- organismal death
- lymphoma
- lymphomagenesis
- growth failure
- Huntington disease
role in cell
- proliferation
- apoptosis
- phosphorylation in
- expression in
- invasion by
- growth
- accumulation in
- formation
- development
- response by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- centrosome
- cytosol
- nuclear envelope
- fibrils
- cellular protrusions
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ranbp1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- nucleocytoplasmic transport
- signal transduction
- positive regulation of mitotic centrosome separation
Cellular Component
Where in the cell the gene product is active
- nuclear envelope
- nucleus
- centrosome
- cytoplasm
- cytosol
- nuclear pore
Molecular Function
What the gene product does at the molecular level
- protein binding
- GDP-dissociation inhibitor activity
- cadherin binding
- GTPase activator activity
- small GTPase binding