Pls1 Gene Summary [Mouse]
Predicted to enable actin filament binding activity. Involved in several processes, including inner ear receptor cell stereocilium organization; intestinal D-glucose absorption; and positive regulation of protein localization to plasma membrane. Acts upstream of or within terminal web assembly. Located in brush border; stereocilium; and terminal web. Is expressed in egg cylinder; female reproductive system; and gut. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 76. Orthologous to human PLS1 (plastin 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Pls1 |
| Official Name | plastin 1 (I-isoform) [Source:MGI Symbol;Acc:MGI:104809] |
| Ensembl ID | ENSMUSG00000049493 |
| Bio databases IDs | |
| Aliases | plastin 1 (I-isoform) |
| Synonyms | AI427122, DFNA76, Fimbrin, I-PLASTIN, plastin 1, plastin 1 (I-isoform), Pls1 predicted |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Pls1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- actin filament binding
- EF-hand, calcium binding motif
- EF-hand domain
- Calponin homology domain
- structural constituent of cytoskeleton
- EF-hand domain pair
- EF hand
- CH1 domain
- calponin homology (CH) domain superfamily
- EFh
- protein binding
Pathways
Biological processes and signaling networks where the Pls1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- lung adenocarcinoma formation
- lung adenocarcinoma
- autosomal dominant deafness type 76
- colitis
- endometriosis
regulates
- actin
- F Actin
role in cell
- apoptosis
- growth
- abnormal morphology
- length
- assembly
- size
- invasion by
- adhesion
- mechanotransduction
- cross-linkage
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
- apical compartment
- perinuclear region
- retraction fibers
- podosomes
- cytosol
- apical cytoplasm
- stereocilia
- apical cell surfaces
- terminal web
- apical membrane
- basolateral membrane
- brush border
- microvilli
- filopodia
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Pls1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- vestibular receptor cell stereocilium organization
- auditory receptor cell stereocilium organization
- intestinal D-glucose absorption
- actin filament network formation
- regulation of microvillus length
- positive regulation of multicellular organism growth
- actin filament bundle assembly
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- brush border
- cytoplasm
- actin filament bundle
- cytosol
- stereocilium
- actin filament
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- actin filament binding
- calcium ion binding
- structural constituent of cytoskeleton