Ly6k Gene Summary [Mouse]
Acts upstream of or within binding activity of sperm to zona pellucida and flagellated sperm motility. Located in acrosomal vesicle; cell surface; and plasma membrane. Is expressed in several structures, including central nervous system; reproductive system; retina; spleen; and stomach. Orthologous to human LY6K (lymphocyte antigen 6 family member K). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ly6k |
| Official Name | lymphocyte antigen 6 complex, locus K [Source:MGI Symbol;Acc:MGI:1923736] |
| Ensembl ID | ENSMUSG00000044678 |
| Bio databases IDs | |
| Aliases | lymphocyte antigen 6 complex, locus K |
| Synonyms | 2410015A16RIK, 3110035B01Rik, CT97, HSJ001348, lymphocyte antigen 6 family member K, mLy-6K, URLC10 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ly6k often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein binding
- TFP
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- cervical cancer
- HER2 negative hormone receptor negative breast cancer
- organismal death
role in cell
- expression in
- proliferation
- migration
- colony formation
- motility
- binding
- invasion by
- phosphorylation in
- signaling in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- cell surface
- Extracellular Space
- Plasma Membrane
- acrosome
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ly6k gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- binding of sperm to zona pellucida
Cellular Component
Where in the cell the gene product is active
- acrosomal vesicle
- membrane raft
- extracellular region
- plasma membrane