Fosl2 Gene Summary [Mouse]
Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity and chromatin binding activity. Involved in positive regulation of DNA-templated transcription. Acts upstream of or within several processes, including cartilage development; leukocyte differentiation; and lung development. Located in nucleus. Is expressed in several structures, including alimentary system; genitourinary system; skeleton; skin; and telencephalon. Used to study idiopathic pulmonary fibrosis and systemic scleroderma. Orthologous to human FOSL2 (FOS like 2, AP-1 transcription factor subunit). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Fosl2 |
| Official Name | fos-like antigen 2 [Source:MGI Symbol;Acc:MGI:102858] |
| Ensembl ID | ENSMUSG00000029135 |
| Bio databases IDs | |
| Aliases | fos-like antigen 2 |
| Synonyms | ACED, FLJ23306, FOS like 2, AP-1 transcription factor subunit, fos-like antigen 2, FRA2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Fosl2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- activation domain
- transcription regulator
- nucleic acid binding
- leucine zipper domain
- chromatin binding
- protein binding
- sequence-specific DNA binding
- DNA binding
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- double-stranded DNA binding
- bZIP
- transcription factor activity
- basic region leucin zipper
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- aplasia cutis-enamel dysplasia syndrome
- diabetes mellitus
- lymphomagenesis
- endometriosis
- inflammatory bowel disease
- growth failure
- osteosarcomagenesis
- allergy
- neurodevelopmental disorder
- HER2 negative hormone receptor negative breast cancer
role in cell
- expression in
- number
- binding in
- proliferation
- activation in
- growth
- motility
- differentiation
- apoptosis
- cell cycle progression
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- nucleoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Fosl2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- multicellular organism growth
- regulation of multicellular organism growth
- chondrocyte differentiation
- lung connective tissue development
- fat cell differentiation
- response to xenobiotic stimulus
- positive regulation of transcription from RNA polymerase II promoter
- keratinocyte development
- cell death
- response to hypoxia
- NK T cell differentiation
- inflammatory response to antigenic stimulus
- positive regulation of fibroblast proliferation
- response to glucocorticoid stimulus
- osteoblast differentiation
- collagen biosynthetic process
- neutrophil differentiation
- T cell receptor signaling pathway
- macrophage differentiation
- alveolar secondary septum development
- bone mineralization
- B cell differentiation
- cell morphogenesis
- fat pad development
- smooth muscle tissue development
- B cell proliferation
- regulation of transcription from RNA polymerase II promoter
- tissue remodeling
- osteoclast differentiation
- mucus secretion
- homeostasis of number of cells within a tissue
- growth plate cartilage development
- innate immune response
- glucose homeostasis
- gene expression
- chondrocyte proliferation
- response to lipopolysaccharide
- response to interleukin-13
Cellular Component
Where in the cell the gene product is active
- nucleus
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- sequence-specific DNA binding transcription factor activity
- protein binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- RNA polymerase II regulatory region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
- chromatin binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity