Slc25a26 Gene Summary [Mouse]
Predicted to enable S-adenosyl-L-methionine:S-adenosyl-L-homocysteine antiporter activity. Predicted to be involved in mitochondrial S-adenosyl-L-methionine transmembrane transport. Located in mitochondrion. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 28. Orthologous to human SLC25A26 (solute carrier family 25 member 26). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Slc25a26 |
| Official Name | solute carrier family 25 (mitochondrial carrier, phosphate carrier), member 26 [Source:MGI Symbol;Acc:MGI:1914832] |
| Ensembl ID | ENSMUSG00000045100 |
| Bio databases IDs | |
| Aliases | solute carrier family 25 (mitochondrial carrier, phosphate carrier), member 26 |
| Synonyms | 4930433D19RIK, 4933433F13Rik, COXPD28, D6BWG0781E, SAMC, Slc25a6, solute carrier family 25 member 26, solute carrier family 25 (mitochondrial carrier, phosphate carrier), member 26 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Slc25a26 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- purine nucleoside transporter
- S-adenosylmethionine transporter
- Mitochondrial carrier protein
- antiporter
- L-amino acid transporter
- transporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- insulin resistance
- hereditary disorder
- combined oxidative phosphorylation deficiency 28
- colorectal adenoma
- colorectal adenoma formation
- atrial fibrillation
- sarcoidosis
- lymphocytic leukemia
- binge eating disorder
regulates
- ion
- S-adenosylmethionine
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Mitochondria
- mitochondrial inner membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Slc25a26 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- ion transport
- purine nucleoside transport
- S-adenosylmethionine transport
- macromolecule methylation
Cellular Component
Where in the cell the gene product is active
- mitochondrion
- mitochondrial inner membrane
Molecular Function
What the gene product does at the molecular level
- S-adenosylmethionine transmembrane transporter activity