Trim39 Gene Summary [Mouse]
Predicted to enable identical protein binding activity and ubiquitin protein ligase activity. Predicted to be involved in several processes, including protein stabilization; regulation of cell cycle phase transition; and regulation of signal transduction. Predicted to be located in mitochondrion and nucleus. Predicted to be active in cytosol. Is expressed in several structures, including cardiovascular system; central nervous system; genitourinary system; gut; and immune system. Orthologous to human TRIM39 (tripartite motif containing 39). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Nonsense Mediated Decay |
| Official Symbol | Trim39 |
| Official Name | tripartite motif-containing 39 [Source:MGI Symbol;Acc:MGI:1890659] |
| Ensembl ID | ENSMUSG00000045409 |
| Bio databases IDs | |
| Aliases | tripartite motif-containing 39 |
| Synonyms | 1100001D15Rik, E130103K13Rik, mKIAA4179, RBCC-B30.2, RNF23, TFP, TRIM39B, tripartite motif-containing 39 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Trim39 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- coiled-coil (CC) domain of Drosophila brain tumor (brat) and similar proteins
- B-Box C-terminal domain
- SPRY domain
- zinc finger of C3HC4-type, RING
- F-type ATP synthase, membrane subunit b
- protein binding
- identical protein binding
- associated with SPRY domains
- B-box-type zinc finger superfamily
- RING-type zinc-finger
- RING finger (Really Interesting New Gene) domain and U-box domain superfamily
- Modified RING finger domain
- Ring finger
- B-box zinc finger
- RING-H2 zinc finger domain
- SPRY-associated domain
- Zinc finger, C3HC4 type (RING finger)
- zinc-RING finger domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cutaneous lupus erythematosus
- chronic interstitial cystitis
regulated by
- hematopoietic progenitor cells
- T lymphocytes
role in cell
- apoptosis
- growth
- degradation in
- accumulation in
- G1/S phase transition
- cell cycle progression
- destabilization in
- polyubiquitination in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- Endoplasmic Reticulum
- Mitochondria
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Trim39 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- mitotic cell cycle G2/M transition DNA damage checkpoint
- apoptotic process
- negative regulation of I-kappaB kinase/NF-kappaB cascade
- protein stabilization
- positive regulation of apoptotic signaling pathway
- protein ubiquitination
- negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
- negative regulation of proteasomal ubiquitin-dependent protein catabolic process
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- mitochondrion
- cytosol
Molecular Function
What the gene product does at the molecular level
- zinc ion binding
- identical protein binding
- protein binding