Trim39 Gene Summary [Rat]
Predicted to enable ribonuclease P RNA binding activity. Predicted to contribute to ribonuclease P activity. Predicted to be involved in response to xenobiotic stimulus and tRNA 5'-leader removal. Predicted to be part of multimeric ribonuclease P complex. Orthologous to human RPP21 (ribonuclease P/MRP subunit p21). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Trim39 |
| Official Name | tripartite motif-containing 39 [Source:RGD Symbol;Acc:1303115] |
| Ensembl ID | ENSRNOG00000000785 |
| Bio databases IDs | |
| Aliases | tripartite motif-containing 39 |
| Synonyms | 1100001D15Rik, E130103K13Rik, mKIAA4179, RBCC-B30.2, RNF23, TFP, TRIM39B, tripartite motif-containing 39 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Trim39 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- coiled-coil (CC) domain of Drosophila brain tumor (brat) and similar proteins
- B-Box C-terminal domain
- SPRY domain
- zinc finger of C3HC4-type, RING
- F-type ATP synthase, membrane subunit b
- protein binding
- identical protein binding
- associated with SPRY domains
- B-box-type zinc finger superfamily
- RING-type zinc-finger
- RING finger (Really Interesting New Gene) domain and U-box domain superfamily
- Modified RING finger domain
- Ring finger
- B-box zinc finger
- RING-H2 zinc finger domain
- SPRY-associated domain
- Zinc finger, C3HC4 type (RING finger)
- zinc-RING finger domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cutaneous lupus erythematosus
- chronic interstitial cystitis
regulated by
- hematopoietic progenitor cells
- T lymphocytes
role in cell
- apoptosis
- growth
- degradation in
- accumulation in
- G1/S phase transition
- cell cycle progression
- destabilization in
- polyubiquitination in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- Endoplasmic Reticulum
- Mitochondria
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Trim39 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- mitotic cell cycle G2/M transition DNA damage checkpoint
- apoptotic process
- negative regulation of I-kappaB kinase/NF-kappaB cascade
- protein stabilization
- positive regulation of apoptotic signaling pathway
- protein ubiquitination
- negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
- negative regulation of proteasomal ubiquitin-dependent protein catabolic process
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- mitochondrion
- cytosol
Molecular Function
What the gene product does at the molecular level
- zinc ion binding
- identical protein binding
- protein binding