Insm2 Gene Summary [Mouse]
Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and transcription corepressor activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II; neuron differentiation; and regulation of cell cycle process. Predicted to act upstream of or within negative regulation of DNA-templated transcription. Predicted to be located in cytoplasm. Predicted to be part of transcription repressor complex. Predicted to be active in nucleus. Is expressed in several structures, including adrenal gland; central nervous system; eye; genitourinary system; and pancreas. Orthologous to human INSM2 (INSM transcriptional repressor 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Insm2 |
| Official Name | insulinoma-associated 2 [Source:MGI Symbol;Acc:MGI:1930787] |
| Ensembl ID | ENSMUSG00000045440 |
| Bio databases IDs | |
| Aliases | insulinoma-associated 2 |
| Synonyms | IA-6, INSM transcriptional repressor 2, insulinoma-associated 2, Mlt1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Insm2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Zinc finger, C2H2 type
- zinc finger
- transcription regulator
- transcription co-repressor
- C2H2-type zinc finger
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Insm2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- neuron differentiation
- regulation of cell cycle process
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- transcriptional repressor complex
Molecular Function
What the gene product does at the molecular level
- metal ion binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription