Ndrg3 Gene Summary [Mouse]
Involved in decidualization. Predicted to be active in cytoplasm. Is expressed in several structures, including central nervous system; dorsal root ganglion; forelimb interdigital region mesenchyme; genitourinary system; and thymus primordium. Orthologous to human NDRG3 (NDRG family member 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ndrg3 |
| Official Name | N-myc downstream regulated gene 3 [Source:MGI Symbol;Acc:MGI:1352499] |
| Ensembl ID | ENSMUSG00000027634 |
| Bio databases IDs | |
| Aliases | N-myc downstream regulated gene 3 |
| Synonyms | 4833415O14Rik, LOC100366265, LOC108348290, NDR3, NDRG family member 3, N-myc downstream regulated gene 3 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ndrg3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- alpha/beta hydrolase fold
- alpha/beta hydrolases
- Ndr family
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Huntington disease
- melanoma
- melanoma cancer
- non-melanoma skin cancer
role in cell
- expression in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cell cortex
- synaptic vesicles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ndrg3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- signal transduction
- negative regulation of cell growth
- spermatogenesis
- cell differentiation
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- cytoplasm