Rhou Gene Summary [Mouse]
Enables GTPase activity. Acts upstream of or within several processes, including G1/S transition of mitotic cell cycle; Rac protein signal transduction; and regulation of cell shape. Predicted to be located in several cellular components, including Golgi membrane; focal adhesion; and podosome. Predicted to be active in plasma membrane. Is expressed in several structures, including branchial pouch; cerebral cortex; ganglia; gut; and hair follicle. Orthologous to human RHOU (ras homolog family member U). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Retained Intron |
| Official Symbol | Rhou |
| Official Name | ras homolog family member U [Source:MGI Symbol;Acc:MGI:1916831] |
| Ensembl ID | ENSMUSG00000039960 |
| Bio databases IDs | |
| Aliases | ras homolog family member U |
| Synonyms | 2310026M05Rik, ARHU, CDC42L1, G28K, hG28K, LOC678766, mG28K, ras homolog family member U, Rhoul1, WRCH-1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Rhou often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- effector loop
- Small GTPase of the Ras superfamily (ill-defined subfamily)
- Ras family
- GTPase
- enzyme
- protein binding
- proline rich domain
- Ras subfamily of RAS small GTPases
- small GTP-binding protein domain
- guanyl-nucleotide exchange factor
- Rab subfamily of small GTPases
- Ras of Complex, Roc, domain of DAPkinase
- Rho (Ras homology) subfamily of Ras-like small GTPases
- P-loop containing Nucleoside Triphosphate Hydrolases
Pathways
Biological processes and signaling networks where the Rhou gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- Actin Nucleation by ARP-WASP Complex
- Cholecystokinin/Gastrin-mediated Signaling
- CXCR4 Signaling
- Germ Cell-Sertoli Cell Junction Signaling
- Glioblastoma Multiforme Signaling
- Glioma Invasiveness Signaling
- Gαq Signaling
- HMGB1 Signaling
- IL-8 Signaling
- ILK Signaling
- Integrin Signaling
- mTOR Signaling
- Production of Nitric Oxide and Reactive Oxygen Species in Macrophages
- Regulation of Actin-based Motility by Rho
- RhoGDI Signaling
- Semaphorin Signaling in Neurons
- Serotonin Receptor Signaling
- Signaling by Rho Family GTPases
- Sphingosine-1-phosphate Signaling
- Tec Kinase Signaling
- Thrombin Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- adenomyosis
- T acute lymphoblastic leukemia
- chronic lymphocytic leukemia
- autosomal dominant polycystic kidney disease
role in cell
- expression in
- migration
- G1/S phase transition
- adhesion
- proliferation
- dissociation
- growth
- formation
- organization
- turnover in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
- Plasma Membrane
- cytosol
- endosomal membrane
- early endosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Rhou gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- Rac protein signal transduction
- regulation of cell shape
- cytoskeleton organization
- regulation of small GTPase mediated signal transduction
- establishment or maintenance of cell polarity
- G1/S transition of mitotic cell cycle
- actin filament organization
- Cdc42 protein signal transduction
- endocytosis
Cellular Component
Where in the cell the gene product is active
- focal adhesion
- cytosol
- Golgi membrane
- endosome membrane
- cell projection
- plasma membrane
- podosome
Molecular Function
What the gene product does at the molecular level
- GTP binding
- protein kinase binding
- protein binding
- metal ion binding
- GTPase activity
- guanyl-nucleotide exchange factor activity