Trim23 Gene Summary [Mouse]
Predicted to enable several functions, including GTPase activity; guanyl ribonucleotide binding activity; and identical protein binding activity. Predicted to be involved in several processes, including intracellular protein transport; positive regulation of metabolic process; and protein ubiquitination. Located in cytoplasm and nucleus. Is expressed in ureter. Orthologous to human TRIM23 (tripartite motif containing 23). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Trim23 |
| Official Name | tripartite motif-containing 23 [Source:MGI Symbol;Acc:MGI:1933161] |
| Ensembl ID | ENSMUSG00000021712 |
| Bio databases IDs | |
| Aliases | tripartite motif-containing 23 |
| Synonyms | 6330516O20Rik, ARD1, ARFD1, RNF46, tripartite motif-containing 23 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Trim23 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- coiled-coil (CC) domain of Drosophila brain tumor (brat) and similar proteins
- B-Box C-terminal domain
- Ras family
- ubiquitin protein ligase activity
- GTPase
- enzyme
- protein binding
- GTPase Activating Protein domain
- enzyme activator activity
- identical protein binding
- ARF domain
- GTP binding
- Sar1p-like members of the Ras-family of small GTPases
- ADP-ribosylation factor family
- B-box-type zinc finger superfamily
- RING-type zinc-finger
- GDP binding
- Ring finger
- RING finger (Really Interesting New Gene) domain and U-box domain superfamily
- ubiquitin-protein transferase activity
- B-box zinc finger
- Ras of Complex, Roc, domain of DAPkinase
- ADP-ribosylation factor
- P-loop containing Nucleoside Triphosphate Hydrolases
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- colorectal cancer
- organismal death
role in cell
- proliferation
- activation in
- synthesis in
- autophagy by
- K27 polyubiquitination in
- innate immune response in
- ubiquitination in
- K63 polyubiquitination in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- cellular membrane
- vesicles
- lysosome
- Golgi Apparatus
- Golgi membrane
- lysosome membrane
- lysosomal compartment
- perinuclear space
- cytoplasmic vesicles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Trim23 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of autophagy
- vesicle-mediated transport
- innate immune response
- intracellular protein transport
- protein ubiquitination
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- Golgi membrane
- lysosomal membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- GTP binding
- ubiquitin-protein ligase activity
- identical protein binding
- zinc ion binding
- protein binding
- GTPase activity
- GDP binding
- enzyme activator activity