Tmprss12 Gene Summary [Mouse]
Predicted to enable serine-type endopeptidase activity. Involved in acrosome assembly and positive regulation of sperm capacitation. Acts upstream of or within binding activity of sperm to zona pellucida and protein processing. Located in acrosomal vesicle. Orthologous to human TMPRSS12 (transmembrane serine protease 12). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tmprss12 |
| Official Name | transmembrane (C-terminal) protease, serine 12 [Source:MGI Symbol;Acc:MGI:1922252] |
| Ensembl ID | ENSMUSG00000045631 |
| Bio databases IDs | |
| Aliases | transmembrane (C-terminal) protease, serine 12 |
| Synonyms | 4930478A21Rik, CT151, RGD1560236, transmembrane (C-terminal) protease, serine 12, transmembrane serine protease 12 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Tmprss12 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Trypsin-like serine protease
- trypsin
- Tryp_SPc
- peptidase
- Domain of unknown function (DUF1986)
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- acrosome
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Tmprss12 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- acrosome assembly
- binding of sperm to zona pellucida
- spermatogenesis
- protein processing
Cellular Component
Where in the cell the gene product is active
- acrosomal vesicle
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- serine-type endopeptidase activity