Zmpste24 Gene Summary [Mouse]
Enables double-stranded DNA binding activity and metalloendopeptidase activity. Involved in nuclear envelope organization and protein maturation. Acts upstream of or within several processes, including heart development; regulation of intracellular signal transduction; and regulation of primary metabolic process. Located in membrane and nuclear envelope. Is expressed in early conceptus and oocyte. Used to study Emery-Dreifuss muscular dystrophy; familial partial lipodystrophy; and progeria. Human ortholog(s) of this gene implicated in mandibuloacral dysplasia type B lipodystrophy; restrictive dermopathy; and restrictive dermopathy 1. Orthologous to human ZMPSTE24 (zinc metallopeptidase STE24). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Zmpste24 |
| Official Name | zinc metallopeptidase, STE24 [Source:MGI Symbol;Acc:MGI:1890508] |
| Ensembl ID | ENSMUSG00000043207 |
| Bio databases IDs | |
| Aliases | zinc metallopeptidase, STE24 |
| Synonyms | A530043O15Rik, CAAX ENDOPROTEASE, D030046F19, FACE-1, HGPS, MADB, PRO1, RSDM1, STE24, Ste24p, zinc metallopeptidase STE24, zinc metallopeptidase, STE24 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Zmpste24 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- endopeptidase
- Peptidase family M48
- metalloexopeptidase
- double-stranded DNA binding
- peptidase
- Peptidase_M48_M56
- protein binding
- CAAX prenyl protease N-terminal, five membrane helices
- metalloendopeptidase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- weight loss
- progressive muscle weakness
- micrognathia
- weight gain
- breast carcinoma
- familial partial lipodystrophy
- gait disturbance
- alopecia
- lethal restrictive dermopathy
- bradycardia
regulated by
- GGTI-298
- geranylgeranyl transferase inhibitor unspecified
- IgG
- tipranavir
- lopinavir
role in cell
- apoptosis
- activation in
- proliferation
- autophagy in
- function
- morphology
- growth
- invasiveness
- senescence
- cell cycle progression
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- pH resistant lipid raft fraction
- detergent resistant lipid raft fraction
- cellular membrane
- endoplasmic reticulum membrane
- nuclear envelope
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Zmpste24 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of cell shape
- multicellular organism growth
- DNA repair
- regulation of multicellular organism growth
- determination of adult lifespan
- regulation of hormone metabolic process
- cellular lipid metabolic process
- regulation of ventricular cardiomyocyte membrane repolarization
- cardiac ventricle development
- cardiac conduction
- thymus development
- maintenance of rDNA
- prenylated protein catabolic process
- adult walking behavior
- nuclear envelope organization
- heart morphogenesis
- ventricular cardiac muscle tissue development
- hair follicle development
- liver development
- regulation of fibroblast proliferation
- regulation of stress-activated protein kinase signaling cascade
- regulation of termination of RNA polymerase I transcription
- protein maturation
- response to DNA damage checkpoint signal
- regulation of cellular senescence
- regulation of TOR signaling cascade
- regulation of bone mineralization
- regulation of DNA damage response, signal transduction by p53 class mediator
- kidney morphogenesis
- bone mineralization
- neuromuscular process
- hypomethylation of CpG island
- cellular response to gamma radiation
- regulation of glucose metabolic process
- CAAX-box protein processing
- growth plate cartilage development
- inflammatory cell apoptotic process
- regulation of autophagy
- proteolysis
- cardiac muscle cell development
- regulation of lipid metabolic process
- regulation of defense response to virus
Cellular Component
Where in the cell the gene product is active
- early endosome membrane
- endoplasmic reticulum membrane
- late endosome membrane
- nuclear inner membrane
- extracellular vesicular exosome
- membrane
- macromolecular complex
Molecular Function
What the gene product does at the molecular level
- protein binding
- metal ion binding
- endopeptidase activity
- double-stranded DNA binding
- metalloexopeptidase activity
- metalloendopeptidase activity