Sidt2 Gene Summary [Mouse]
Enables several functions, including AP-1 adaptor complex binding activity; AP-2 adaptor complex binding activity; and nucleic acid transmembrane transporter activity. Involved in RNA catabolic process and RNA transport. Acts upstream of or within several processes, including regulation of insulin secretion involved in cellular response to glucose stimulus; type B pancreatic cell development; and type B pancreatic cell proliferation. Located in lysosomal membrane and plasma membrane. Is expressed in several structures, including inner ear; submandibular gland primordium; and vibrissa. Used to study metabolic dysfunction-associated steatotic liver disease. Orthologous to human SIDT2 (SID1 transmembrane family member 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Sidt2 |
| Official Name | SID1 transmembrane family, member 2 [Source:MGI Symbol;Acc:MGI:2446134] |
| Ensembl ID | ENSMUSG00000034908 |
| Bio databases IDs | |
| Aliases | SID1 transmembrane family, member 2 |
| Synonyms | B930096O19, CGI-40, RGD1308311, SID1 transmembrane family member 2, SID1 transmembrane family, member 2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Sidt2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- binding protein
- nucleobase, nucleoside, nucleotide and nucleic acid transporter
- dsRNA-gated channel SID-1
- double-stranded RNA binding
- protein binding
- transporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- breast cancer
- impaired glucose tolerance
- fibrosis
- hepatic steatosis
- ulcerative colitis
- metabolic syndrome X
- islets of Langerhans hyperplasia
- peripheral arterial disease
role in cell
- accumulation in
- cell death
- quantity
- accumulation
- abnormal morphology
- number
- maturation
- autophagic flux in
- morphogenesis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
- Plasma Membrane
- lysosome
- lysosome membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Sidt2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of insulin secretion involved in cellular response to glucose stimulus
- response to glucose stimulus
- cell morphogenesis
- type B pancreatic cell proliferation
- glucose homeostasis
- RNA transport
- type B pancreatic cell development
- RNA catabolic process
Cellular Component
Where in the cell the gene product is active
- lysosomal membrane
- plasma membrane
- lysosome
Molecular Function
What the gene product does at the molecular level
- DNA binding
- AP-1 adaptor complex binding
- RNA transmembrane transporter activity
- double-stranded RNA binding
- nucleic acid transmembrane transporter activity
- AP-2 adaptor complex binding