Sprn Gene Summary [Mouse]
Enables nucleic acid binding activity. Acts upstream of or within protein import into nucleus. Located in several cellular components, including cytosol; nucleolus; and vesicle. Is expressed in cerebellum; embryo; and olfactory epithelium. Orthologous to human SPRN (shadow of prion protein). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Sprn |
| Official Name | shadow of prion protein [Source:MGI Symbol;Acc:MGI:3582583] |
| Ensembl ID | ENSMUSG00000045733 |
| Bio databases IDs | |
| Aliases | shadow of prion protein |
| Synonyms | bA108K14.1, C630041J07, SHADOO, shadow of prion protein, SHO |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Sprn often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Shadow of prion protein, neuroprotective
- nucleic acid binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Extracellular Space
- cellular membrane
- Plasma Membrane
- vesicles
- cytosol
- nucleoli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Sprn gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein import into nucleus
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytosol
- vesicle
- nucleolus
- extracellular region
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- nucleic acid binding