Fyn Gene Summary [Mouse]
Enables several functions, including cytoskeletal protein binding activity; protein tyrosine kinase activity; and transmembrane transporter binding activity. Involved in several processes, including negative regulation of dendritic spine maintenance; positive regulation of tyrosine phosphorylation of STAT protein; and reelin-mediated signaling pathway. Acts upstream of or within several processes, including activated T cell proliferation; negative regulation of protein metabolic process; and nervous system development. Located in several cellular components, including actin filament; membrane raft; and postsynaptic density. Is active in Schaffer collateral - CA1 synapse. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Used to study skin disease and skin squamous cell carcinoma. Human ortholog(s) of this gene implicated in Alzheimer's disease; alcohol dependence; and schizophrenia. Orthologous to human FYN (FYN proto-oncogene, Src family tyrosine kinase). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Fyn |
| Official Name | Fyn proto-oncogene [Source:MGI Symbol;Acc:MGI:95602] |
| Ensembl ID | ENSMUSG00000019843 |
| Bio databases IDs | |
| Aliases | Fyn proto-oncogene |
| Synonyms | C-FYN, Fyn proto-oncogene, FYN proto-oncogene, Src family tyrosine kinase, FYNT, LOC102724705, p59-FYN, p59 Fyn B, SLK, SRC-LIKE KINASE, SYN |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Fyn often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Csk phosphorylation site
- protein kinase
- growth factor receptor binding
- regulatory domain
- membrane-association domain
- G-protein-coupled receptor binding
- T-cell receptor binding
- ephrin receptor binding
- enzyme
- protein-tyrosine kinase
- Protein kinase domain
- unique protein domain
- phospholipase activator
- identical protein binding
- tau protein binding
- tubulin binding
- myristoylation sequence
- CD8 receptor binding
- alpha-tubulin binding
- ion channel binding
- Src homology 2 (SH2) domain
- ETGE motif
- Tyrosine kinase, catalytic domain
- myristoylation site
- SH4 domain
- palmitoylation site
- Protein kinase (unclassified specificity)
- catalytic domain
- Protein tyrosine and serine/threonine kinase
- enzyme binding
- linker domain
- non-membrane spanning protein tyrosine kinase
- protein domain specific binding
- protein binding
- receptor binding
- CD4 receptor binding
- Src Homology 3 domain superfamily
- kinase
- Serine/Threonine protein kinases, catalytic domain
- SH2-catalytic domain linker
- kinase domain
- phosphoinositide 3-kinase binding
- binding protein
- Protein Kinases, catalytic domain
- membrane attachment signal
Pathways
Biological processes and signaling networks where the Fyn gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- Caveolar-mediated Endocytosis Signaling
- Ephrin A Signaling
- Ephrin Receptor Signaling
- Epithelial Adherens Junction Signaling
- Fc Epsilon RI Signaling
- Fcγ Receptor-mediated Phagocytosis in Macrophages and Monocytes
- GP6 Signaling Pathway
- HER-2 Signaling in Breast Cancer
- IL-15 Production
- IL-7 Signaling Pathway
- Inhibition of Angiogenesis by TSP1
- Insulin Receptor Signaling
- Integrin Signaling
- Natural Killer Cell Signaling
- Prolactin Signaling
- Reelin Signaling in Neurons
- Regulation of IL-2 Expression in Activated and Anergic T Lymphocytes
- Role of Tissue Factor in Cancer
- Semaphorin Signaling in Neurons
- Sperm Motility
- Virus Entry via Endocytic Pathways
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- obesity
- weight loss
- schizophrenia
- bipolar disorder
- Parkinson disease
- neoplasia
- oligozoospermia
- cancer
- COVID-19
role in cell
- dephosphorylation in
- expression in
- proliferation
- activation
- differentiation
- phosphorylation in
- binding
- quantity
- number
- apoptosis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- detergent-insoluble membrane fraction
- microsomal fraction
- myelin enriched fraction
- raft fractions
- postsynaptic density (PSD) fractions
- detergent-insoluble fractions
- membrane fraction
- glutaminergic synapse
- organelle
- Cytoplasm
- cell surface
- cell periphery
- perinuclear region
- intracellular membranes
- cellular membrane
- cell cortex
- Nucleus
- endosomes
- vesicles
- Mitochondria
- membrane compartment
- actin filaments
- immunological synapses
- granules
- cytoplasmic aggregates
- cytosol
- cytoplasmic face of plasma membrane
- reticular perinuclear compartment
- caveolae
- plasma membrane projections
- growth cone
- neurites
- synaptosomes
- synapse
- glial cell projections
- membrane rafts
- detergent insoluble microdomains
- cleavage furrow
- membrane processes
- mitotic spindle
- perikaryon
- axons
- dendrites
- postsynaptic density
- plasma
- detergent-soluble fraction
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Fyn gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- peptidyl-tyrosine phosphorylation
- negative regulation of protein catabolic process
- axon guidance
- positive regulation of tyrosine phosphorylation of STAT protein
- G-protein coupled glutamate receptor signaling pathway
- learning
- heart process
- forebrain development
- positive regulation of neuron projection development
- negative regulation of protein ubiquitination
- intracellular signal transduction
- negative regulation of hydrogen peroxide biosynthetic process
- activated T cell proliferation
- positive regulation of protein localization to nucleus
- cellular response to platelet-derived growth factor stimulus
- adaptive immune response
- response to singlet oxygen
- dendritic spine maintenance
- cellular response to transforming growth factor beta stimulus
- negative regulation of gene expression
- vascular endothelial growth factor receptor signaling pathway
- ephrin receptor signaling pathway
- regulation of synaptic transmission
- gene expression
- detection of mechanical stimulus involved in sensory perception of pain
- positive regulation of cysteine-type endopeptidase activity
- protein ubiquitination
- regulation of cell shape
- positive regulation of protein targeting to membrane
- feeding behavior
- Fc-gamma receptor signaling pathway involved in phagocytosis
- protein phosphorylation
- stimulatory C-type lectin receptor signaling pathway
- dendrite morphogenesis
- response to ethanol
- regulation of peptidyl-tyrosine phosphorylation
- neuron migration
- calcium ion transport
- cellular response to hydrogen peroxide
- T cell receptor signaling pathway
- T cell costimulation
- protein catabolic process
- transmembrane receptor protein tyrosine kinase signaling pathway
- regulation of glutamate receptor signaling pathway
- negative regulation of inflammatory response to antigenic stimulus
- innate immune response
- cell differentiation
- leukocyte migration
Cellular Component
Where in the cell the gene product is active
- postsynaptic density
- actin filament
- perikaryon
- plasma membrane
- nucleus
- dendrite
- perinuclear region of cytoplasm
- endosome
- perinuclear endoplasmic reticulum
- mitochondrion
- membrane raft
- cell body
- cytosol
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- ephrin receptor binding
- alpha-tubulin binding
- ion channel binding
- receptor binding
- tau-protein kinase activity
- type 5 metabotropic glutamate receptor binding
- scaffold protein binding
- ATP binding
- protein tyrosine kinase activity
- protein binding
- non-membrane spanning protein tyrosine kinase activity
- metal ion binding
- phospholipase binding
- tau protein binding
- growth factor receptor binding
- phospholipase activator activity
- enzyme binding