Hsp90b1 Gene Summary [Mouse]
Predicted to enable several functions, including ATP binding activity; ATP hydrolysis activity; and low-density lipoprotein particle receptor binding activity. Predicted to be involved in ERAD pathway; insulin processing; and protein folding. Predicted to act upstream of or within actin rod assembly and cellular response to ATP. Located in endoplasmic reticulum and sperm plasma membrane. Part of endoplasmic reticulum chaperone complex. Is expressed in several structures, including central nervous system; heart; metanephros; pancreas; and respiratory system. Used to study male infertility due to globozoospermia. Orthologous to several human genes including HSP90B1 (heat shock protein 90 beta family member 1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Retained Intron |
| Official Symbol | Hsp90b1 |
| Official Name | heat shock protein 90, beta (Grp94), member 1 [Source:MGI Symbol;Acc:MGI:98817] |
| Ensembl ID | ENSMUSG00000020048 |
| Bio databases IDs | |
| Aliases | heat shock protein 90, beta (Grp94), member 1 |
| Synonyms | ECGP, endoplasmin, ENPL, ERP99, FLJ22209, GP96, GRP94, heat shock protein 90 beta family member 1, heat shock protein 90, beta (Grp94), member 1, heat shock protein 90 β family member 1, heat shock protein 90, β (Grp94), member 1, HEL35, HEL-S-125m, HSP96, HSP GP96 precursor, TA-3, TARG2, TRA1, Tumor rejection antigen gp96, tumour rejection antigen gp96 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Hsp90b1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- dimerization domain
- endoplasmic reticulum retrieval sequence
- Histidine kinase-like ATPase domain
- protein phosphatase binding
- calcium ion binding
- signal peptide
- central domain
- low-density lipoprotein receptor binding
- protein binding
- acidic domain
- RNA binding
- protein phosphatase inhibitor activity
- Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
- Hsp90 protein
- PRK05218
- Histidine kinase-like ATPases
- glycosylation site
Pathways
Biological processes and signaling networks where the Hsp90b1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- Aldosterone Signaling in Epithelial Cells
- Aryl Hydrocarbon Receptor Signaling
- Cellular Effects of Sildenafil (Viagra)
- Endoplasmic Reticulum Stress Pathway
- eNOS Signaling
- Estrogen Receptor Signaling
- Glucocorticoid Receptor Signaling
- Human Embryonic Stem Cell Pluripotency
- Hypoxia Signaling in the Cardiovascular System
- IL-17 Signaling
- Mitotic Roles of Polo-Like Kinase
- Neuregulin Signaling
- Nitric Oxide Signaling in the Cardiovascular System
- NRF2-mediated Oxidative Stress Response
- PPAR Signaling
- PPARα/RXRα Activation
- Prostate Cancer Signaling
- Role of JAK family kinases in IL-6-type Cytokine Signaling
- Role of PKR in Interferon Induction and Antiviral Response
- Telomerase Signaling
- Th17 Activation Pathway
- Unfolded protein response
- Xenobiotic Metabolism Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- plasma cell myeloma
- relapsed multiple myeloma
- malignant pleural effusion
- neoplasia
- colorectal cancer
- metastatic breast cancer
- locally advanced breast cancer
- recurrent breast cancer
- advanced breast cancer
- epithelial cancer
role in cell
- quantity
- growth
- activation
- expression in
- proliferation
- differentiation
- apoptosis
- binding in
- activation in
- formation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- microsomal fraction
- nuclear fraction
- nuclear membrane fraction
- membrane fraction
- pH resistant lipid raft fraction
- detergent resistant lipid raft fraction
- endoplasmic reticulum mitochondria contact site
- cilia
- cell surface
- Extracellular Space
- perinuclear region
- organelle lumens
- cellular membrane
- Nucleus
- Plasma Membrane
- endosomes
- vesicles
- Golgi Apparatus
- Endoplasmic Reticulum
- midbody
- lipid droplets
- cytosol
- endoplasmic reticulum compartments
- endoplasmic reticulum membrane
- endoplasmic reticulum lumen
- microsome
- smooth endoplasmatic reticulum
- exosomes
- plasma
- phagocytic cups
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Hsp90b1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein transport
- regulation of phosphoprotein phosphatase activity
- protein folding
- response to hypoxia
- negative regulation of apoptotic process
- cellular response to manganese ion
- retrograde protein transport, ER to cytosol
- sequestering of calcium ion
- cellular response to ATP
- response to endoplasmic reticulum stress
- actin rod assembly
- protein folding in endoplasmic reticulum
Cellular Component
Where in the cell the gene product is active
- smooth endoplasmic reticulum
- endoplasmic reticulum
- extracellular region
- endoplasmic reticulum membrane
- endoplasmic reticulum lumen
- nucleus
- extracellular vesicular exosome
- perinuclear region of cytoplasm
- focal adhesion
- melanosome
- endocytic vesicle lumen
- membrane
- cytosol
- macromolecular complex
- endoplasmic reticulum chaperone complex
- midbody
- sarcoplasmic reticulum lumen
Molecular Function
What the gene product does at the molecular level
- ATPase activity
- ATP binding
- RNA binding
- protein phosphatase binding
- low-density lipoprotein particle receptor binding
- protein binding
- calcium ion binding
- unfolded protein binding