Slitrk6 Gene Summary [Mouse]
Acts upstream of or within several processes, including auditory behavior; linear vestibuloocular reflex; and nervous system development. Located in cell periphery. Is expressed in several structures, including brain; gut; limb bud; lung; and sensory organ. Used to study high myopia-sensorineural deafness syndrome and sensorineural hearing loss. Human ortholog(s) of this gene implicated in high myopia-sensorineural deafness syndrome. Orthologous to human SLITRK6 (SLIT and NTRK like family member 6). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Slitrk6 |
| Official Name | SLIT and NTRK-like family, member 6 [Source:MGI Symbol;Acc:MGI:2443198] |
| Ensembl ID | ENSMUSG00000045871 |
| Bio databases IDs | |
| Aliases | SLIT and NTRK-like family, member 6 |
| Synonyms | 4832410J21RIK, DFNMYP, SLIT and NTRK like family member 6, SLIT and NTRK-like family, member 6, Sltk6 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Slitrk6 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Leucine-rich repeats, outliers
- Leucine-rich repeats, typical (most populated) subfamily
- protein phosphatase 1 regulatory subunit 42
- Leucine rich repeat
- Leucine rich repeat C-terminal domain
- BspA type Leucine rich repeat region (6 copies)
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hearing loss
- hyperactive behavior
- myopia
- deafness and myopia
- deafness and myopia syndrome
- global developmental delay
role in cell
- function
- development
- abnormal morphology
- assembly
- innervation
- morphogenesis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- cell periphery
- cellular membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Slitrk6 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- multicellular organism growth
- cochlea development
- auditory receptor cell morphogenesis
- innervation
- adult locomotory behavior
- visual perception
- lens development in camera-type eye
- vestibulocochlear nerve development
- linear vestibuloocular reflex
- sensory perception of sound
- synapse assembly
- startle response
- axonogenesis
- auditory behavior
- positive regulation of synapse assembly
Cellular Component
Where in the cell the gene product is active
- plasma membrane
- cell surface