Sav1 Gene Summary [Mouse]
Predicted to enable identical protein binding activity; protein serine/threonine kinase activator activity; and transcription regulator activator activity. Involved in hippo signaling. Acts upstream of or within several processes, including epithelial cell differentiation; negative regulation of cell population proliferation; and positive regulation of keratinocyte apoptotic process. Predicted to be located in cytoplasm and nucleus. Predicted to be active in cytosol. Is expressed in several structures, including genitourinary system; heart; liver; lung; and spleen. Used to study colonic disease and hepatocellular carcinoma. Orthologous to human SAV1 (salvador family WW domain containing protein 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Sav1 |
| Official Name | salvador family WW domain containing 1 [Source:MGI Symbol;Acc:MGI:1927144] |
| Ensembl ID | ENSMUSG00000021067 |
| Bio databases IDs | |
| Aliases | salvador family WW domain containing 1 |
| Synonyms | 1700040G09Rik, Salv, salvador family WW domain containing 1, salvador family WW domain containing protein 1, SAV, WW45, Wwp3, WWP4 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Sav1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein kinase activator
- SARAH_SF
- SARAH domain
- Domain with 2 conserved Trp (W) residues
- WW
- protein binding
- identical protein binding
- WW domain
Pathways
Biological processes and signaling networks where the Sav1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- epithelial neoplasia
- cancer
- benign neoplasia
- neoplasia
- adenoma formation
- gastric cancer
- tumorigenesis
- hyperplasia
- cholangiocarcinoma cancer
phenotypes
- abnormal enterocyte morphology
- abnormal enterocyte proliferation
- abnormal epidermis stratum basale morphology
- abnormal epidermis stratum granulosum morphology
- abnormal intestinal enteroendocrine cell morphology
- abnormal intestinal goblet cell morphology
- abnormal keratinocyte differentiation
- abnormal large intestine crypts of Lieberkuhn morphology
- abnormal lung development
- abnormal oval cell morphology
- abnormal placental labyrinth vasculature morphology
- abnormal small intestinal microvillus morphology
- abnormal small intestinal villus morphology
- bile duct hyperplasia
- decreased survivor rate
- disorganized suprabasal layer
- epidermal hyperplasia
- fetal growth retardation
- impaired skin barrier function
- increased enterocyte cell number
- increased hepatocellular carcinoma incidence
- increased hepatoma incidence
- increased liver adenoma incidence
- increased liver tumor incidence
- increased lymphoma incidence
- increased osteosarcoma incidence
- increased ovary tumor incidence
- lethality throughout fetal growth and development incomplete penetrance
- lung epithelium hyperplasia
- parakeratosis
- premature death
- prenatal lethality complete penetrance
- retina hyperplasia
- underdeveloped hair follicles
role in cell
- expression in
- phosphorylation in
- apoptosis
- differentiation
- migration
- proliferation
- binding in
- number
- abnormal morphology
- invasion by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- centrosome
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Sav1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of cardiac muscle cell proliferation
- lung epithelial cell differentiation
- intestinal epithelial cell differentiation
- negative regulation of cell proliferation
- positive regulation of fat cell differentiation
- keratinocyte apoptotic process
- cardiac muscle cell proliferation
- ventricular septum morphogenesis
- keratinocyte differentiation
- epithelial cell proliferation
- hair follicle development
- positive regulation of apoptotic process
- negative regulation of epithelial cell proliferation
- regulation of stem cell maintenance
- hippo signaling cascade
- protein stabilization
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- cytosol
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein serine/threonine kinase activator activity
- protein binding
- binding, bridging