Tapt1 Gene Summary [Mouse]
Acts upstream of or within embryonic skeletal system development. Predicted to be located in centrosome; cytosol; and nucleoplasm. Predicted to be active in ciliary basal body and endoplasmic reticulum membrane. Is expressed in several structures, including central nervous system; genitourinary system; liver; lung; and retina layer. Orthologous to human TAPT1 (transmembrane anterior posterior transformation 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tapt1 |
| Official Name | transmembrane anterior posterior transformation 1 [Source:MGI Symbol;Acc:MGI:2683537] |
| Ensembl ID | ENSMUSG00000046985 |
| Bio databases IDs | |
| Aliases | transmembrane anterior posterior transformation 1 |
| Synonyms | 4932414K18Rik, CMVFR, OCLSBG, RGD1309656, transmembrane anterior posterior transformation 1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Tapt1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- growth hormone-releasing hormone receptor
- Eukaryotic membrane protein family
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Symoens-Barnes-Gistelinck type complex lethal osteochondrodysplasia
phenotypes
- abnormal skeleton morphology
- abnormal sternocostal joint morphology
- anemia
- cleft palate
- lumbar vertebral transformation
- perinatal lethality complete penetrance
- split xiphoid process
- thoracic vertebral transformation
role in cell
- assembly
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cellular membrane
- basal bodies
- centrosome
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Tapt1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of cartilage development
- G-protein coupled receptor signaling pathway
- ossification
- neural crest cell development
- cell projection organization
- positive regulation of flagellum assembly
- embryonic skeletal system development
- cartilage development
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- centrosome
- cilium basal body
- membrane
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- growth hormone-releasing hormone receptor activity