Dlgap2 Gene Summary [Mouse]
Predicted to enable molecular adaptor activity and protein domain specific binding activity. Involved in regulation of postsynaptic neurotransmitter receptor activity. Is active in glutamatergic synapse and postsynaptic density, intracellular component. Is expressed in cranium and nervous system. Orthologous to human DLGAP2 (DLG associated protein 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Dlgap2 |
| Official Name | DLG associated protein 2 [Source:MGI Symbol;Acc:MGI:2443181] |
| Ensembl ID | ENSMUSG00000047495 |
| Bio databases IDs | |
| Aliases | DLG associated protein 2 |
| Synonyms | 6430596N04RIK, C8orf68, DAP-2, Disks large-associated protein 2, DLG associated protein 2, ERICH1-AS1, SAPAP2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Dlgap2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein domain specific binding
- protein binding
- Guanylate-kinase-associated protein (GKAP) protein
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- COVID-19
- depressive disorder
- non-small cell lung cancer
- diabetic nephropathy
- epiphora
- lung carcinoma
- lung carcinoma process
- acute myeloid leukemia
- myopia
- breast cancer
regulates
- DLGAP2
- carboplatin
role in cell
- function
- abnormal morphology
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- synaptic spine
- glutaminergic synapse
- organelle
- Cytoplasm
- postsynaptic region
- membrane surface
- cellular membrane
- dendritic spines
- dendritic spine head
- synaptosomes
- synapse
- perikaryon
- dendrites
- postsynaptic density
- excitatory synapses
- dendritic shafts
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Dlgap2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- neuron-neuron synaptic transmission
Cellular Component
Where in the cell the gene product is active
- postsynaptic density
- neurofilament
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- binding, bridging