Prkaa2 Gene Summary [Mouse]
Enables AMP-activated protein kinase activity; chromatin binding activity; and histone H2BS36 kinase activity. Involved in several processes, including regulation of autophagy; regulation of organelle organization; and regulation of protein modification process. Acts upstream of or within several processes, including cellular response to prostaglandin E stimulus; cellular response to xenobiotic stimulus; and response to muscle activity. Located in several cellular components, including cytoplasmic stress granule; dendrite; and neuronal cell body. Is active in cytosol. Is expressed in several structures, including brain; genitourinary system; gut; lung; and spinal cord. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human PRKAA2 (protein kinase AMP-activated catalytic subunit alpha 2). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Prkaa2 |
| Official Name | protein kinase, AMP-activated, alpha 2 catalytic subunit [Source:MGI Symbol;Acc:MGI:1336173] |
| Ensembl ID | ENSMUSG00000028518 |
| Bio databases IDs | |
| Aliases | protein kinase, AMP-activated, alpha 2 catalytic subunit |
| Synonyms | 2310008I11Rik, A830082D05, AMPK, AMPK2, AMPKa2, AMPK alpha2, Ampk catalytic subunit alpha2, Hmg CoA Rk, PRKAA, protein kinase, AMP-activated, alpha 2 catalytic subunit, protein kinase AMP-activated catalytic subunit alpha 2, protein kinase AMP-activated catalytic subunit α 2, protein kinase, AMP-activated, α 2 catalytic subunit |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Prkaa2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- UBA domain-like superfamily
- protein serine/threonine kinase
- protein threonine/tyrosine kinase
- Protein kinase (unclassified specificity)
- protein kinase
- catalytic domain
- Protein tyrosine and serine/threonine kinase
- protein binding activity, bridging
- ATP binding
- chromatin binding
- enzyme
- protein binding
- Protein kinase domain
- SNF1A/AMP-activated protein kinase
- kinase
- Serine/Threonine protein kinases, catalytic domain
- kinase domain
- binding protein
- Protein Kinases, catalytic domain
- AMPKA_C_like
- alcohol group acceptor phosphotransferase
- Kinase-like
- Tyrosine kinase, catalytic domain
Pathways
Biological processes and signaling networks where the Prkaa2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- AMPK Signaling
- Apelin Adipocyte Signaling Pathway
- Apelin Cardiac Fibroblast Signaling Pathway
- Apelin Endothelial Signaling Pathway
- Apelin Muscle Signaling Pathway
- Apelin Pancreas Signaling Pathway
- Autophagy
- Chronic Myeloid Leukemia Signaling
- Circadian Rhythm Signaling
- Docosahexaenoic Acid (DHA) Signaling
- Endocannabinoid Cancer Inhibition Pathway
- eNOS Signaling
- Epithelial Adherens Junction Signaling
- Estrogen Receptor Signaling
- Glucocorticoid Receptor Signaling
- IL-10 Signaling
- IL-12 Signaling and Production in Macrophages
- mTOR Signaling
- Osteoarthritis Pathway
- PPARα/RXRα Activation
- Sirtuin Signaling Pathway
- Type II Diabetes Mellitus Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- colorectal carcinomagenesis
- epithelial cancer
- obesity
- heart disease
- hepatocellular carcinoma
- liver cancer
- reticulocytosis
- diabetes mellitus
- retinal degeneration
role in cell
- replication in
- accumulation in
- formation
- formation in
- phosphorylation in
- apoptosis
- expression in
- activation in
- differentiation
- growth
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cilia
- Nucleus
- basal bodies
- Golgi Apparatus
- cytosol
- microsome
- apical membrane
- nucleoplasm
- nuclear speckles
- stress granule
- perikaryon
- axons
- dendrites
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Prkaa2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of microtubule cytoskeleton organization
- protein phosphorylation
- regulation of circadian rhythm
- cellular response to prostaglandin E stimulus
- positive regulation of glycolysis
- chromatin remodeling
- cellular response to calcium ion
- cellular response to glucose stimulus
- autophagy
- positive regulation of peptidyl-lysine acetylation
- energy homeostasis
- Wnt receptor signaling pathway
- negative regulation of TOR signaling cascade
- positive regulation of macroautophagy
- response to muscle activity
- signal transduction
- fatty acid homeostasis
- lipid biosynthetic process
- cholesterol biosynthetic process
- fatty acid biosynthetic process
- cellular response to glucose starvation
- negative regulation of gene expression
- positive regulation of autophagy
- cellular response to nutrient levels
- rhythmic process
- negative regulation of apoptotic process
- glucose homeostasis
- regulation of macroautophagy
- cellular response to oxidative stress
- cellular response to xenobiotic stimulus
Cellular Component
Where in the cell the gene product is active
- nucleus
- dendrite
- cytoplasmic stress granule
- cytoplasm
- nuclear speck
- cytosol
- Golgi apparatus
- neuronal cell body
- axon
- nucleoplasm
- AMP-activated protein kinase complex
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein serine/threonine/tyrosine kinase activity
- AMP-activated protein kinase activity
- protein binding
- [hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity
- metal ion binding
- protein kinase activity
- chromatin binding
- protein serine/threonine kinase activity