Ubash3b Gene Summary [Mouse]
Enables phosphoprotein binding activity and protein tyrosine phosphatase activity. Involved in regulation of osteoclast differentiation. Acts upstream of or within several processes, including collagen-activated tyrosine kinase receptor signaling pathway; negative regulation of bone resorption; and negative regulation of platelet aggregation. Predicted to be located in nucleus. Predicted to be active in cytoplasm. Is expressed in several structures, including central nervous system; incisor; limb; nasal cavity epithelium; and retina. Orthologous to human UBASH3B (ubiquitin associated and SH3 domain containing B). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ubash3b |
| Official Name | ubiquitin associated and SH3 domain containing, B [Source:MGI Symbol;Acc:MGI:1920078] |
| Ensembl ID | ENSMUSG00000032020 |
| Bio databases IDs | |
| Aliases | ubiquitin associated and SH3 domain containing, B |
| Synonyms | 2810457I06Rik, KIAA1959, p70, RGD1310357, STS-1, TULA-2, ubiquitin associated and SH3 domain containing B, ubiquitin associated and SH3 domain containing, B |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ubash3b often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- UBA domain-like superfamily
- ubiquitin protein ligase binding
- protein-tyrosine-phoshatase
- Histidine phosphatase superfamily (branch 1)
- Phosphoglycerate mutase family
- phosphoprotein binding
- enzyme
- Histidine phosphatase domain
- protein binding
- alpha-ribazole phosphatase
- identical protein binding
- Src Homology 3 domain superfamily
Pathways
Biological processes and signaling networks where the Ubash3b gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- COVID-19
- cardiovascular disorder
- experimental autoimmune encephalomyelitis
- systemic lupus erythematosus
- preeclampsia
- cerebral atherosclerosis
role in cell
- differentiation
- phosphorylation in
- activation in
- tyrosine phosphorylation in
- proliferation
- number
- signaling in
- autophagy by
- aggregation
- degranulation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Unknown
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ubash3b gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of release of sequestered calcium ion into cytosol
- negative regulation of signal transduction
- regulation of osteoclast differentiation
- negative regulation of platelet aggregation
- negative regulation of osteoclast differentiation
- collagen-activated tyrosine kinase receptor signaling pathway
- negative regulation of bone resorption
- platelet aggregation
- negative regulation of protein kinase activity
- peptidyl-tyrosine dephosphorylation
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- ubiquitin protein ligase binding
- protein tyrosine phosphatase activity
- phosphoprotein binding