Lonp2 Gene Summary [Mouse]
Predicted to enable peptidase activity and protease binding activity. Predicted to be involved in protein processing; protein targeting to peroxisome; and regulation of fatty acid beta-oxidation. Located in cytoplasm and nucleus. Is expressed in future brain; future prosencephalon; head; neural tube; and remnant of Rathke's pouch. Orthologous to human LONP2 (lon peptidase 2, peroxisomal). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Lonp2 |
| Official Name | lon peptidase 2, peroxisomal [Source:MGI Symbol;Acc:MGI:1914137] |
| Ensembl ID | ENSMUSG00000047866 |
| Bio databases IDs | |
| Aliases | lon peptidase 2, peroxisomal |
| Synonyms | 1300002A08Rik, LOC100507577, LONP, lon peptidase 2, peroxisomal, LONPL, LRRGT00016, PLON, PSLON, RGD1305466, Riken cDNA 1300002a08 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Lonp2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- AAA domain (dynein-related subfamily)
- endopeptidase La
- ATPase family associated with various cellular activities (AAA)
- protease binding
- ATP-dependent protease La (LON) substrate-binding domain
- peptidase
- Lon protease (S16) C-terminal proteolytic domain
- enzyme binding
- protein binding
- AAA domain (Cdc48 subfamily)
- P-loop containing Nucleoside Triphosphate Hydrolases
- ATPases associated with a variety of cellular activities
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- peroxisomal matrix
- Nucleus
- cytosol
- peroxisomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Lonp2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein import into peroxisome matrix
- regulation of fatty acid beta-oxidation
- misfolded or incompletely synthesized protein catabolic process
- protein targeting to peroxisome
- peroxisome organization
- protein processing
- response to organic cyclic compound
Cellular Component
Where in the cell the gene product is active
- nucleus
- peroxisome
- membrane
- cytosol
- peroxisomal matrix
Molecular Function
What the gene product does at the molecular level
- ATPase activity
- ATP binding
- protein binding
- serine-type endopeptidase activity
- protease binding
- peptidase activity
- ATP-dependent peptidase activity
- enzyme binding