Map4 Gene Summary [Mouse]
Enables microtubule binding activity. Involved in microtubule cytoskeleton organization. Acts upstream of or within establishment of spindle orientation; microtubule sliding; and mitotic spindle organization. Located in postsynaptic density. Is expressed in several structures, including central nervous system; genitourinary system; gut; musculature; and trunk mesenchyme. Orthologous to human MAP4 (microtubule associated protein 4). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Map4 |
| Official Name | microtubule-associated protein 4 [Source:MGI Symbol;Acc:MGI:97178] |
| Ensembl ID | ENSMUSG00000032479 |
| Bio databases IDs | |
| Aliases | microtubule-associated protein 4 |
| Synonyms | Microtubule Associated Protein 3, microtubule-associated protein 4, Mtap-4 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Map4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- projection domain
- microtubule binding
- microtubule binding domain
- Family of unknown function (DUF5585)
- Tau and MAP protein, tubulin-binding repeat
- affinity domain
- tail domain
- protein binding
- structural molecule
- proline rich domain
- Serine Proline motif
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- myocardial infarction
- esophageal squamous cell carcinoma
- esophageal squamous cell cancer
- metabolic syndrome X
- neonatal late-onset sepsis
- breast carcinoma
- COVID-19
- schizophrenia
- organismal death
role in cell
- cell death
- quantity
- phosphorylation in
- apoptosis
- migration
- disassembly
- binding
- invasion by
- replication in
- outgrowth
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- microtubule aster fraction
- soluble fraction
- microtubule cytoskeleton
- cilia
- Plasma Membrane
- basal bodies
- microtubules
- axonemes
- microtubule organizing centers
- cytosol
- mitotic spindle
- axons
- postsynaptic density
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Map4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell division
- neuron projection development
- microtubule sliding
- mitotic spindle organization
- establishment of spindle orientation
- microtubule polymerization
- microtubule cytoskeleton organization
Cellular Component
Where in the cell the gene product is active
- microtubule cytoskeleton
- mitotic spindle
- microtubule organizing center
- cytosol
- neuron projection
- plasma membrane
- axon
- microtubule associated complex
- axoneme
- microtubule
Molecular Function
What the gene product does at the molecular level
- RNA binding
- protein binding
- structural molecule activity
- microtubule binding